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Campo DC | Valor | Idioma |
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dc.contributor.author | Silva Júnior, Ademir de Jesus | - |
dc.contributor.author | Buzzi, Fátima de Campos | - |
dc.contributor.author | Romanos, Maria Teresa Villela | - |
dc.contributor.author | Wagner, Theodoro Marcel | - |
dc.contributor.author | Guimarães, Antônio Fernando de Paula Costa | - |
dc.contributor.author | Cechinel Filho, Valdir | - |
dc.contributor.author | Batista, Ronan | - |
dc.creator | Silva Júnior, Ademir de Jesus | - |
dc.creator | Buzzi, Fátima de Campos | - |
dc.creator | Romanos, Maria Teresa Villela | - |
dc.creator | Wagner, Theodoro Marcel | - |
dc.creator | Guimarães, Antônio Fernando de Paula Costa | - |
dc.creator | Cechinel Filho, Valdir | - |
dc.creator | Batista, Ronan | - |
dc.date.accessioned | 2014-04-03T12:02:39Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14787 | - |
dc.description | Texto completo: acesso restrito. p. 595–600 | pt_BR |
dc.description.abstract | Ethnopharmacological relevance: In traditional medicine, teas made from leaves and bark of Gallesia gorazema are used as antispasmodic, anthelmintic, antihemorrhagic and febrifuge agents. Crude leaves of this plant are also employed as a remedy in the treatment of abscesses, orchitis, gonorrhea and for rheumatic pain relief. this study investigates the presumed antinociceptive and anti-inflammatory activities of leaves and roots Gallesia gorazema (Phytolaccaceae) extracts. The most active extract and its isolated compound, a new natural product, are also evaluated against viruses HSV-1 and HSV-2. Materials and methods: In vivo experiments with mice were used to assess the analgesic and anti-inflammatory activities of Gallesia gorazema extracts. Antiviral activity of extracts and the new natural product was investigated by in vitro experiments. Results: Results show that dichloromethanic root (DRE) and ethanolic leaf (ELE) extracts displayed significant antinociceptive and anti-inflammatory activities in in vivo experiments with mice. Both extracts were also assayed against the herpes simplex viruses HSV-1 and HSV-2, but only DRE was highly active, showing a selective antiviral effect against HSV-1. Phytochemical fractionation of DRE led to the isolation of 28-hydroxyoctacosyl ferulate, a novel natural product, which displayed strong antiviral activity against HSV-1 (EC50=21.6 μg/mL) with a selective index above 9, justifying, at least in part, the high selective antiviral activity observed for DRE. Conclusion: These results suggest that the plant Gallesia gorazema is a potential candidate for the development of novel anti-herpetic phytomedicines. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.jep.2013.09.005 | pt_BR |
dc.subject | Gallesia gorazema | pt_BR |
dc.subject | Antinociceptive and anti-inflammatory activities | pt_BR |
dc.subject | Herpes | pt_BR |
dc.subject | Antiviral activity | pt_BR |
dc.subject | Anti-herpetic phytomedicines | pt_BR |
dc.subject | 28-Hydroxyoctacosyl ferulate | pt_BR |
dc.title | Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines | pt_BR |
dc.title.alternative | Journal of Ethnopharmacology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 150, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
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1-s2.0-S0378874113006387-main.pdf | 449,25 kB | Adobe PDF | Visualizar/Abrir |
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