Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAlmeida, Sintia Silva de-
dc.contributor.authorCosta, Marcilia P.-
dc.contributor.authorDorella, Fernanda Alves-
dc.contributor.authorOliveira, Sérgio Costa-
dc.contributor.authorMiyoshi, Anderson-
dc.contributor.authorAzevedo, Vasco Ariston de Carvalho-
dc.contributor.authorMcCulloch, John Anthony-
dc.contributor.authorFonseca, Cristina Toscano-
dc.contributor.authorOliveira, Diana Magalhães de-
dc.contributor.authorTeixeira, Maria Fátima da Silva-
dc.contributor.authorLaskowska, Ewa-
dc.creatorAlmeida, Sintia Silva de-
dc.creatorCosta, Marcilia P.-
dc.creatorDorella, Fernanda Alves-
dc.creatorOliveira, Sérgio Costa-
dc.creatorMiyoshi, Anderson-
dc.creatorAzevedo, Vasco Ariston de Carvalho-
dc.creatorMcCulloch, John Anthony-
dc.creatorFonseca, Cristina Toscano-
dc.creatorOliveira, Diana Magalhães de-
dc.creatorTeixeira, Maria Fátima da Silva-
dc.creatorLaskowska, Ewa-
dc.descriptionp. 1-10pt_BR
dc.description.abstractBackground Heat shock proteins (HSPs) are important candidates for the development of vaccines because they are usually able to promote both humoral and cellular immune responses in mammals. We identified and characterized the hsp60-hsp10 bicistronic operon of the animal pathogen Corynebacterium pseudotuberculosis, a Gram-positive bacterium of the class Actinobacteria, which causes caseous lymphadenitis (CLA) in small ruminants. Findings To construct the DNA vaccine, the hsp60 gene of C. pseudotuberculosis was cloned in a mammalian expression vector. BALB/c mice were immunized by intramuscular injection with the recombinant plasmid (pVAX1/hsp60). Conclusion This vaccination induced significant anti-hsp60 IgG, IgG1 and IgG2a isotype production. However, immunization with this DNA vaccine did not confer protective immunity.pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMolecular characterization of the Corynebacterium pseudotuberculosis hsp60-hsp10 operon, and evaluation of the immune response and protective efficacy induced by hsp60 DNA vaccination in micept_BR
dc.title.alternativeBMC Research Notespt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 4pt_BR
Appears in Collections:Artigo Publicado em Periódico (Biologia)

Files in This Item:
File Description SizeFormat 
Síntia S Almeida.pdf1,48 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.