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Campo DC | Valor | Idioma |
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dc.contributor.author | Atta, Ajax Mercês | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Jerônimo, S. M. B. | - |
dc.contributor.author | Atta, Maria Luiza Brito de Sousa | - |
dc.creator | Atta, Ajax Mercês | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Jerônimo, S. M. B. | - |
dc.creator | Atta, Maria Luiza Brito de Sousa | - |
dc.date.accessioned | 2014-03-12T17:48:23Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0896-8411 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14732 | - |
dc.description | Texto completo: acesso restrito. p. 55–58 | pt_BR |
dc.description.abstract | Rheumatoid factor (RF) has been described in visceral leishmaniasis (VL). However, there is no report of RF-isotype or other rheumatoid arthritis (RA) autoantibody in VL. This work investigated RF and anti-cyclic citrullinated peptide antibody (CCP-Ab) in sera from 35 inhabitants from a VL area: 15 from healthy persons (HIEA); 10 from VL patients (VL), and 10 from subjects cured of VL (CVL). The controls were represented by sera from 15 healthy individuals (HI) and from 10 RA patients from a VL free area. IgM-RF was investigated by immunoturbidimetry, while IgA-RF and CCP-Ab by enzyme-linked immunosorbent assay (ELISA). Increased RF-IgM production was found in 9 out of 10 sera from both VL and RA groups (median level 100 and 182 IU/ml respectively); in three out of CVL-sera (level 94 IU), and in only one HIEA-serum (level 58 IU). IgA-RF was only detected in RA-sera (5/10, 50%), while CCP-Ab was found in three VL and in four RA sera (median level 36.5 U and 161.5 U respectively). A strong correlation was observed between RF-IgM and VL in endemic area (P < 0.0001). We concluded that an increased IgM-RF production associated with sporadic and moderate CCP-Ab synthesis is an autoimmune characteristic of VL. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.jaut.2006.12.001 | pt_BR |
dc.subject | Autoimmunity | pt_BR |
dc.subject | CCP-Ab | pt_BR |
dc.subject | RF-IgA | pt_BR |
dc.subject | RF-IgM | pt_BR |
dc.subject | Visceral leishmaniasis | pt_BR |
dc.title | Serum markers of rheumatoid arthritis in visceral leishmaniasis: Rheumatoid factor and anti-cyclic citrullinated peptide antibody | pt_BR |
dc.title.alternative | Journal of Autoimmunity | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 28, n. 1 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (FAR) |
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1-s2.0-S0896841106001144-main.pdf | 128,45 kB | Adobe PDF | Visualizar/Abrir |
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