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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14391
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dc.contributor.authorCarvalho, Lucas Pedreira de-
dc.contributor.authorSoto, Manuel-
dc.contributor.authorJerônimo, Selma-
dc.contributor.authorDondji, Blaise-
dc.contributor.authorBacellar, Maria Olívia Amado Ramos-
dc.contributor.authorLuz, Viviane-
dc.contributor.authorOrge, Glória Orge-
dc.contributor.authorAlonso, Carlos-
dc.contributor.authorJesus, Amélia R.-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.creatorCarvalho, Lucas Pedreira de-
dc.creatorSoto, Manuel-
dc.creatorJerônimo, Selma-
dc.creatorDondji, Blaise-
dc.creatorBacellar, Maria Olívia Amado Ramos-
dc.creatorLuz, Viviane-
dc.creatorOrge, Glória Orge-
dc.creatorAlonso, Carlos-
dc.creatorJesus, Amélia R.-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.date.accessioned2014-01-20T15:45:48Z-
dc.date.issued2003-
dc.identifier.issn1286-4579-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/14391-
dc.descriptionTexto completo: acesso restrito. p. 7–12pt_BR
dc.description.abstractLeishmaniases have a high prevalence in tropical countries. In order to improve existing diagnostic systems based on total Leishmania proteins, and to identify antigen candidates for vaccine development, an intensive search for the identification of antigens was performed using molecular biology techniques. In this study, the immune response to three L. infantum recombinant antigens was evaluated. Upon stimulation with KMP11, mononuclear cells from leishmaniasis patients produced high levels of IL-10, while a predominant IFN-γ production could be observed in cultures stimulated with H2A and soluble Leishmania antigen. All the recombinant antigens induced very little IL-5. KMP11 decreased IFN-γ production by 48% in cultures of peripheral blood mononuclear cells from cutaneous leishmaniasis patients who had been stimulated with soluble Leishmania antigen. Furthermore, antibodies to KMP11 were detected in the sera from all patients with visceral leishmaniasis and in the majority of the sera from patients with cutaneous leishmaniasis or individuals with asymptomatic L. chagasi infection. Thus, KMP11 is recognized by cells and sera of patients with different clinical forms of leishmaniasis, and KMP11, through IL-10 production, proved to be a potent antigen in modulating type 1 immune response.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S1286-4579(02)00051-5pt_BR
dc.subjectLeishmaniasispt_BR
dc.subjectImmuneregulationpt_BR
dc.subjectIFN-γpt_BR
dc.subjectKMP11pt_BR
dc.titleCharacterization of the immune response to Leishmania infantum recombinant antigenspt_BR
dc.title.alternativeMicrobes and Infectionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 5, n. 1pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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