Campo DC | Valor | Idioma |
dc.contributor.author | Costa, Dirceu Joaquim | - |
dc.contributor.author | Carvalho, Rayssa M. de Araujo | - |
dc.contributor.author | Abbehusen, Melissa Moura Costa | - |
dc.contributor.author | Teixeira, Clarissa Romero | - |
dc.contributor.author | Pitombo, Maiana Albuquerque | - |
dc.contributor.author | Santos, Joelma Trigo dos | - |
dc.contributor.author | Nascimento, Flávia Raquel Fernandes do | - |
dc.contributor.author | Silva, Lucilene Amorim | - |
dc.contributor.author | Silva, Ana Lucia Abreu | - |
dc.contributor.author | Cruz, Maria do Socorro Pires | - |
dc.contributor.author | Miranda, José Carlos | - |
dc.contributor.author | Fukutani, Kyoshi Ferreira | - |
dc.contributor.author | Oliveira, Camila Indiani de | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Brodskyn, Claudia Ida | - |
dc.creator | Costa, Dirceu Joaquim | - |
dc.creator | Carvalho, Rayssa M. de Araujo | - |
dc.creator | Abbehusen, Melissa Moura Costa | - |
dc.creator | Teixeira, Clarissa Romero | - |
dc.creator | Pitombo, Maiana Albuquerque | - |
dc.creator | Santos, Joelma Trigo dos | - |
dc.creator | Nascimento, Flávia Raquel Fernandes do | - |
dc.creator | Silva, Lucilene Amorim | - |
dc.creator | Silva, Ana Lucia Abreu | - |
dc.creator | Cruz, Maria do Socorro Pires | - |
dc.creator | Miranda, José Carlos | - |
dc.creator | Fukutani, Kyoshi Ferreira | - |
dc.creator | Oliveira, Camila Indiani de | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Brodskyn, Claudia Ida | - |
dc.date.accessioned | 2013-12-16T14:10:09Z | - |
dc.date.available | 2013-12-16T14:10:09Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14187 | - |
dc.description | p. 1-11 | pt_BR |
dc.description.abstract | Background: Canine Visceral Leishmaniasis (CVL) is a zoonotic disease caused by Leishmania infantum, transmitted by the
bite of Lutzomyia longipalpis sand flies. Dogs are the main domestic reservoir of the parasite. The establishment of an
experimental model that partially reproduces natural infection in dogs is very important to test vaccine candidates, mainly
regarding those that use salivary proteins from the vector and new therapeutical approaches.
Methodology/Principal Findings: In this report, we describe an experimental infection in dogs, using intradermal injection
of Leishmania infantum plus salivary gland homogenate (SGH) of Lutzomyia longipalpis. Thirty-five dogs were infected with
16107 parasites combined with five pairs of Lutzomyia longipalpis salivary glands and followed for 450 days after infection
and clinical, immunological and parasitological parameters were evaluated. Two hundred and ten days after infection we
observed that 31,4% of dogs did not display detectable levels of anti-Leishmania antibodies but all presented different
numbers of parasites in the lymph nodes. Animals with a positive xenodiagnosis had at least 3,356105 parasites in their
lymph nodes. An increase of IFN-c and IL-10 levels was detected during infection. Twenty two percent of dogs developed
symptoms of CVL during infection.
Conclusion: The infection model described here shows some degree of similarity when compared with naturally infected
dogs opening new perspectives for the study of CVL using an experimental model that employs the combination of
parasites and sand fly saliva both present during natural transmission. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | PLoS ONE | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0060535&representation=PDF | pt_BR |
dc.subject | Leishmaniasis, Visceral | pt_BR |
dc.subject | Leishmania infantum | pt_BR |
dc.subject | Leishmaniasis Vaccines | pt_BR |
dc.title | Experimental Infection of Dogs with Leishmania and Saliva as a Model to Study Canine Visceral Leishmaniasis | pt_BR |
dc.title.alternative | PLoS ONE | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 8, n. 4 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
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