Campo DC | Valor | Idioma |
dc.contributor.author | Afonso, Lilian | - |
dc.contributor.author | Borges, Valéria de Matos | - |
dc.contributor.author | Cruz, Heloísa | - |
dc.contributor.author | Gomes, Flávia L. Ribeiro | - |
dc.contributor.author | Reis, George A. dos | - |
dc.contributor.author | Dutra, Alberto Augusto Noronha | - |
dc.contributor.author | Clarêncio, Jorge | - |
dc.contributor.author | Oliveira, Camila Indiani de | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Brodskyn, Claudia Ida | - |
dc.creator | Afonso, Lilian | - |
dc.creator | Borges, Valéria de Matos | - |
dc.creator | Cruz, Heloísa | - |
dc.creator | Gomes, Flávia L. Ribeiro | - |
dc.creator | Reis, George A. dos | - |
dc.creator | Dutra, Alberto Augusto Noronha | - |
dc.creator | Clarêncio, Jorge | - |
dc.creator | Oliveira, Camila Indiani de | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Brodskyn, Claudia Ida | - |
dc.date.accessioned | 2013-11-29T19:34:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14028 | - |
dc.description | Texto completo: acesso restrito. p. 389-396 | pt_BR |
dc.description.abstract | Neutrophils are involved in the initial steps of most responses to pathogens. In the present study, we evaluated the effects of the interaction of apoptotic vs. necrotic human neutrophils on macrophage infection by Leishmania amazonensis. Phagocytosis of apoptotic, but not viable, neutrophils by Leishmania-infected macrophages led to an increase in parasite burden via a mechanism dependent on TGF-β1 and PGE2. Conversely, infected macrophages’ uptake of necrotic neutrophils induced killing of L. amazonensis. Leishmanicidal activity was dependent on TNF-α and neutrophilic elastase. Nitric oxide was not involved in the killing of parasites, but the interaction of necrotic neutrophils with infected macrophages resulted in high superoxide production, a process reversed by catalase, an inhibitor of reactive oxygen intermediate production. Initial events after Leishmania infection involve interactions with neutrophils; we demonstrate that phagocytosis of these cells in an apoptotic or necrotic stage can influence the outcome of infection, driving either parasite survival or destruction. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1189/jlb.0108018 | pt_BR |
dc.subject | Apoptosis | pt_BR |
dc.subject | Necrosis | pt_BR |
dc.subject | Phagocytosis | pt_BR |
dc.subject | TGF-β1 | pt_BR |
dc.subject | NE | pt_BR |
dc.subject | Leishmaniose | pt_BR |
dc.title | Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis | pt_BR |
dc.title.alternative | Journal of Leukocyte Biology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 84, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Biologia)
|