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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13890
Tipo: Artigo de Periódico
Título: Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
Título(s) alternativo(s): Bioinformatics
Autor(es): Galvão, Viviane
Miranda, José Garcia Vivas
Santos, Ricardo Ribeiro dos
Autor(es): Galvão, Viviane
Miranda, José Garcia Vivas
Santos, Ricardo Ribeiro dos
Abstract: Motivation: A significant issue in stem cell therapy is to understand the role of this type of cell in the tissue regeneration. To explain this mechanism, an experimental study has quantified that the bone marrow cell transplantation decreases the number of inflammatory cells and reduces the fibrosis area in chagasic mice. Using this experimental data, we have developed an agent-based computational model to investigate the regeneration of the chronic chagasic cardiomyopathy after bone marrow stem cell transplantation. Results: Our model includes six different types of agents: inflammatory cell, fibrosis area, cardiomyocyte, proinflammatory cytokine tumor necrosis factor-α, Trypanosoma cruzi parasite and bone marrow stem cell. This latter promotes apoptosis in inflammatory cells, reduction in the fibrosis area and can differentiate into cardiomyocyte. Proinflammatory cytokine tumor necrosis factor-α can increase the fibrosis area and T.cruzi can increase the number of inflammatory cells. Our results for both apoptosis of inflammatory cells and reduction in the fibrosis area were compared with experimental data. They suggest that the concentration pattern is the most important factor to characterize the kinetics of cardiac tissue regeneration after bone marrow stem cell transplantation.
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13890
Data do documento: 2008
Aparece nas coleções:Artigo Publicado em Periódico (Biologia)

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