https://repositorio.ufba.br/handle/ri/13808
metadata.dc.type: | Artigo de Periódico |
Title: | A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report |
Other Titles: | American Journal of Dermatopathology |
Authors: | Bittencourt, Achilea Candida Lisboa Mota, Karla Oliveira, Rodrigo Freire Farré, Lourdes |
metadata.dc.creator: | Bittencourt, Achilea Candida Lisboa Mota, Karla Oliveira, Rodrigo Freire Farré, Lourdes |
Abstract: | Adult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma associated with the human T-cell lymphotropic virus (HTLV-I). We describe an adult male patient clinically and pathologically diagnosed as mycosis fungoides and treated with chemotherapy after which complete involution of the lesions occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the palmoplantar regions, followed by disseminated vesiculopapules and associated lymphocytosis. A serological test performed at this time revealed HTLV-I infection, and a diagnosis of chronic ATL was made. Monoclonal integration of HTLV-I was detected in peripheral blood mononuclear cells by inverse long polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, and intraepidermal vesicles with atypical lymphocytes and an infiltration of small and atypical CD4+ lymphocytes in the superficial dermis. Proliferative index (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with confirmation of HTLV-I proviral integration. The delay that occurred in diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the same clinical, histopathological, and immunohistochemical features. |
Keywords: | Adult T-cell leukemia/lymphoma Mycosis fungoides HTLV-I infection |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13808 |
Issue Date: | 2009 |
Appears in Collections: | Artigo Publicado em Periódico (Biologia) |
File | Description | Size | Format | |
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00000372-200912000-00021.pdf | 1,02 MB | Adobe PDF | View/Open |
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