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dc.contributor.authorAndrade, Bruno Bezerril-
dc.contributor.authorSantos, Théo Araújo-
dc.contributor.authorLuz, Nívea Farias-
dc.contributor.authorCunha, Antônio Ricardo Khouri-
dc.contributor.authorBozza, Marcelo Torres-
dc.contributor.authorCamargo, Luís Marcelo Aranha-
dc.contributor.authorBarral, Aldina Maria Prado-
dc.contributor.authorBorges, Valéria de Matos-
dc.contributor.authorBarral-Netto, Manoel-
dc.creatorAndrade, Bruno Bezerril-
dc.creatorSantos, Théo Araújo-
dc.creatorLuz, Nívea Farias-
dc.creatorCunha, Antônio Ricardo Khouri-
dc.creatorBozza, Marcelo Torres-
dc.creatorCamargo, Luís Marcelo Aranha-
dc.creatorBarral, Aldina Maria Prado-
dc.creatorBorges, Valéria de Matos-
dc.creatorBarral-Netto, Manoel-
dc.descriptionTexto completo: acesso restrito. p. 1196-1204pt_BR
dc.description.abstractIn many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses. Although intriguing, there is scarce data about the involvement of heme on the regulation of immune responses. In this study, we investigated the relation of free heme and the suppression of anti-inflammatory mediators such as PGE2 and TGF-β in human vivax malaria. Patients with severe disease presented higher hemolysis and higher plasma concentrations of Cu/Zn superoxide dismutase (SOD-1) and lower concentrations of PGE2 and TGF-β than those with mild disease. In addition, there was a positive correlation between SOD-1 concentrations and plasma levels of TNF-α. During antimalaria treatment, the concentrations of plasma SOD-1 reduced whereas PGE2 and TGF-β increased in the individuals severely ill. Using an in vitro model with human mononuclear cells, we demonstrated that the heme effect on the impairment of the production of PGE2 and TGF-β partially involves heme binding to CD14 and depends on the production of SOD-1. Aside from furthering the current knowledge about the pathogenesis of vivax malaria, the present results may represent a general mechanism for hemolytic diseases and could be useful for future studies of therapeutic approaches.pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleHeme impairs prostaglandin E2 and TGF-β production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malariapt_BR
dc.title.alternativeJournal of Immunologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 185, n. 2pt_BR
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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