Campo DC | Valor | Idioma |
dc.contributor.author | Santos, Claire da Silva | - |
dc.contributor.author | Boaventura, Viviane Sampaio | - |
dc.contributor.author | Cardoso, Cristina Ribeiro | - |
dc.contributor.author | Tavares, Natália Machado | - |
dc.contributor.author | Lordelo, Morgana de Jesus | - |
dc.contributor.author | Noronha, Almério Libório Lopes de | - |
dc.contributor.author | Noronha, Almério Libório Lopes de | - |
dc.contributor.author | Costa, Jackson | - |
dc.contributor.author | Borges, Valéria de Matos | - |
dc.contributor.author | Oliveira, Camila Indiani de | - |
dc.contributor.author | Weyenbergh, Johan Van | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Brodskyn, Claudia Ida | - |
dc.creator | Santos, Claire da Silva | - |
dc.creator | Boaventura, Viviane Sampaio | - |
dc.creator | Cardoso, Cristina Ribeiro | - |
dc.creator | Tavares, Natália Machado | - |
dc.creator | Lordelo, Morgana de Jesus | - |
dc.creator | Noronha, Almério Libório Lopes de | - |
dc.creator | Noronha, Almério Libório Lopes de | - |
dc.creator | Costa, Jackson | - |
dc.creator | Borges, Valéria de Matos | - |
dc.creator | Oliveira, Camila Indiani de | - |
dc.creator | Weyenbergh, Johan Van | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Brodskyn, Claudia Ida | - |
dc.date.accessioned | 2013-11-06T20:59:24Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13576 | - |
dc.description | Restrito: p. 1533-1540 | pt_BR |
dc.description.abstract | A protective or deleterious role of CD8þT cells in human cutaneous leishmaniasis (CL) has been debated. The
present report explores the participation of CD8þT cells in disease pathogenesis as well as in parasite killing.
CD8þT cells accumulated in CL lesions as suggested by a higher frequency of CD8þCD45ROþT cells and
CD8þCLAþT cells compared with peripheral blood mononuclear cells. Upon Leishmania braziliensis restimulation,
most of the CD8þT cells from the lesion expressed cytolytic markers, CD107a and granzyme B. Granzyme B
expression in CL lesions positively correlated with lesion size and percentage of TUNEL-positive cells. We also
observed a significantly higher percentage of TUNEL-positive cells and granzyme B expression in the biopsies of
patients showing a more intense necrotic process. Furthermore, coculture of infected macrophages and CD8þ
T lymphocytes resulted in the release of granzyme B, and the use of granzyme B inhibitor, as well as z-VAD, Fas:Fc,
or anti-IFN-g, had no effect upon parasite killing. However, coculture of infected macrophages with CD4þT cells
strongly increased parasite killing, which was completely reversed by anti-IFN-g. Our results reveal a dichotomy
in human CL: CD8þ granzyme BþT cells mediate tissue injury, whereas CD4þIFN-gþT cells mediate parasite
killing. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Journal of Investigative Dermatology | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://www.nature.com/jid/journal/v133/n6/pdf/jid20134a.pdf | pt_BR |
dc.subject | Leishmania braziliensis | pt_BR |
dc.subject | CD8 þ T cells | pt_BR |
dc.subject | Granzyme B | pt_BR |
dc.subject | Macrophages | pt_BR |
dc.title | CD8þ Granzyme Bþ–Mediated Tissue Injury vs. CD4þIFNcþ–Mediated Parasite Killing in Human Cutaneous Leishmaniasis | pt_BR |
dc.title.alternative | Journal of Investigative Dermatology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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