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dc.contributor.authorAraújo, Caliandra Pinto-
dc.contributor.authorGurgel, Clarissa Araújo Silva-
dc.contributor.authorRamos, Eduardo Antônio Gonçalves-
dc.contributor.authorFreitas, Valéria Souza-
dc.contributor.authorBarbosa Júnior, Aryon de Almeida-
dc.contributor.authorRamalho, Luciana Maria Pedreira-
dc.contributor.authorSantos, Jean Nunes dos-
dc.creatorAraújo, Caliandra Pinto-
dc.creatorGurgel, Clarissa Araújo Silva-
dc.creatorRamos, Eduardo Antônio Gonçalves-
dc.creatorFreitas, Valéria Souza-
dc.creatorBarbosa Júnior, Aryon de Almeida-
dc.creatorRamalho, Luciana Maria Pedreira-
dc.creatorSantos, Jean Nunes dos-
dc.descriptionTexto completo: acesso restrito. p.357-365pt_BR
dc.description.abstractLCs and MCs are known to be directly influenced by UV radiation. This study investigated the presence of Langerhans cells (LCs) and mast cells (MCs) in actinic cheilitis (AC) exhibiting epithelial dysplasia (ED). Using immunohistochemistry for CD1a and mast cell tryptase, LCs and MCs density was assessed in 35 cases of AC with different degrees of ED. LCs were found in 32 cases of AC whereas MCs were found in all cases. There was an increase in LCs density irrespective of degree of ED when the cases were compared to normal lip mucosa (P = 0.04343). No statistical difference in LCs density was observed regarding the different degrees of dysplasia (P > 0.05). Significant difference in MCs density between mild and moderate dysplasia and normal lip mucosa was found (P < 0.05). No significant correlation between LCs and MCs was seen (P = 0.1258). Although no correlation could be established between LCs and MCs and the different degrees of ED; it is possible that the accumulation of LCs plays an immunostimulatory and protective role in the defense against progression of dysplasia. Further studies are necessary to determine the role of MCs in the development of AC.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectActinic chelitispt_BR
dc.subjectLangerhans cellspt_BR
dc.subjectMast cellspt_BR
dc.subjectEpithelial dysplasiapt_BR
dc.titleAccumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitispt_BR
dc.title.alternativeJournal of Molecular Histologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 41, n. 6pt_BR
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Odontologia)

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