Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13495
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dc.contributor.authorOliveira, Ludmila-
dc.contributor.authorAndrade, Zilton de Araújo-
dc.creatorOliveira, Ludmila-
dc.creatorAndrade, Zilton de Araújo-
dc.date.accessioned2013-11-01T19:19:56Z-
dc.date.available2013-11-01T19:19:56Z-
dc.date.issued2005-
dc.identifier.issn0037-8682-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/13495-
dc.descriptionp.464-468pt_BR
dc.description.abstractLesions involving the intra-hepatic biliary ducts in schistosomiasis have been reported in the literature, both in mice and man, but there are no data concerning their quantitative, evolutionary or post curative chemotherapeutic aspects on record. In order to obtain such data an investigation on this subject was attempted. Mice infected with 50 Schistosoma mansoni cercariae were submitted to a liver biopsy at the 9th week post-infection, and treated with 400mg/bw praziquantel immediately afterwards. Infected and non-infected controls were submitted to the same procedures. By 19 weeks from cercarial exposure all surviving animals were sacrificed. The biliary ducts were counted on histological sections and the results were expressed as biliary ducts/portal spaces. This quantitative evaluation was compared with that from normal controls and revealed hyperplasia as the main biliary duct change (p<0.007) in schistosomiasis. Hyperplastic changes underwent only mild partial and not statistically significant regression after specific chemotherapy (p>0.05). Infected and untreated animals presented ductal changes that did not differ from those of the treated group. Measurements of serum bilirrubin (total and direct), and gamma-glutamyl-transpeptidase (g-GT) did not reveal significant differences when animals from the several groups were compared. Thus, bile ducts exhibit a proliferative response in relation to neighboring S. mansoni injury to portal areas, but although these lesions are histopathologically impressive, they lack a functional or prognostic significance.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/10.1590/S0037-86822005000600003pt_BR
dc.subjectSchistosoma mansonipt_BR
dc.subjectHepatic schistosomiasispt_BR
dc.subjectBile ductspt_BR
dc.titleSignificance of bile-duct changes in schistosomiasispt_BR
dc.title.alternativeRevista da Sociedade Brasileira de Medicina Tropicalpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv.38 n. 6pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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