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dc.contributor.authorBecker, Jefferson-
dc.contributor.authorCallegaro, Dagoberto-
dc.contributor.authorLana-Peixoto, Marco Aurélio-
dc.contributor.authorFerreira, Maria Lúcia B.-
dc.contributor.authorMelo, Ailton de Souza-
dc.contributor.authorGama, Paulo Diniz da-
dc.contributor.authorSouza, Doralina G. B.-
dc.contributor.authorTeixeira, Carlos A. C.-
dc.contributor.authorKaimen-Maciel, Damacio Ramón-
dc.contributor.authorGonçalves, Marcus Vinícius-
dc.contributor.authorMatta, André P. C.-
dc.contributor.authorAbraham, Ronaldo-
dc.contributor.authorFurtado, Luís Edmundo T. A.-
dc.contributor.authorLino, Angelina-
dc.contributor.authorHauck, Laura-
dc.contributor.authorBarreira, Amilton Antunes-
dc.contributor.authorGomes, Irenio-
dc.creatorBecker, Jefferson-
dc.creatorCallegaro, Dagoberto-
dc.creatorLana-Peixoto, Marco Aurélio-
dc.creatorFerreira, Maria Lúcia B.-
dc.creatorMelo, Ailton de Souza-
dc.creatorGama, Paulo Diniz da-
dc.creatorSouza, Doralina G. B.-
dc.creatorTeixeira, Carlos A. C.-
dc.creatorKaimen-Maciel, Damacio Ramón-
dc.creatorGonçalves, Marcus Vinícius-
dc.creatorMatta, André P. C.-
dc.creatorAbraham, Ronaldo-
dc.creatorFurtado, Luís Edmundo T. A.-
dc.creatorLino, Angelina-
dc.creatorHauck, Laura-
dc.creatorBarreira, Amilton Antunes-
dc.creatorGomes, Irenio-
dc.descriptionp. 6–10pt_BR
dc.description.abstractRisk factors for development of multiple sclerosis (MS) are still a matter of debate. Latitude gradient, vitamin D deficiency and season of birth are among the most investigated environmental factors associated with the disease. Several international studies suggest that birth in spring is a substantial risk factor for MS. We investigated the season of birth as a potential risk for MS in different geographical regions of Brazil. We conducted a cross-sectional retrospective study with 2257 clinically definite MS patients enrolled in 13 Brazilian MS clinics in the south, southeast, and northeast regions of Brazil. Demographic and clinical data relating to date of birth and clinical features of the disease were collected and analysed, and subsequently compared with birth date among the general Brazilian population. The distribution of date of birth of MS patients showed an increase in spring and a decrease in autumn, with no difference being observed in the other seasons. In conclusion, season of birth is a probable risk factor for MS in most parts of Brazil. These findings may be related to the role that vitamin D plays in MS pathogenesis.pt_BR
dc.publisherJournal of the Neurological Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSeason of birthpt_BR
dc.subjectMonth of birthpt_BR
dc.subjectRisk factorpt_BR
dc.subjectMultiple sclerosispt_BR
dc.subjectVitamin Dpt_BR
dc.subjectMS epidemiologypt_BR
dc.titleSeason of birth as a risk factor for multiple sclerosis in Brazilpt_BR
dc.title.alternativeJournal of the Neurological Sciencespt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 329, n. 1–2pt_BR
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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