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Campo DC | Valor | Idioma |
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dc.contributor.author | Burns Junior, James M. | - |
dc.contributor.author | Shreffler, Wayne G. | - |
dc.contributor.author | Benson, Darin R. | - |
dc.contributor.author | Ghalib, Hashim W. | - |
dc.contributor.author | Badaró, Roberto José da Silva | - |
dc.contributor.author | Reed, Steven G. | - |
dc.creator | Burns Junior, James M. | - |
dc.creator | Shreffler, Wayne G. | - |
dc.creator | Benson, Darin R. | - |
dc.creator | Ghalib, Hashim W. | - |
dc.creator | Badaró, Roberto José da Silva | - |
dc.creator | Reed, Steven G. | - |
dc.date.accessioned | 2013-10-30T17:51:51Z | - |
dc.date.available | 2013-10-30T17:51:51Z | - |
dc.date.issued | 1993 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13339 | - |
dc.description | p. 775-779 | pt_BR |
dc.description.abstract | We report the cloning of a Leishmania chagasi antigen gene and an evaluation of leishmaniasis patient antibody responses to the recombinant protein, rK39. rK39 contains a 39-amino acid repeat that is part of a 230-kDa protein predominant in L. chagasi tissue amastigotes. Sequence analyses showed this protein, LcKin, to be related to the kinesin superfamily of motor proteins. Southern blot analyses demonstrated LcKin-related sequences in seven species of Leishmania, with conservation of the repeat between L. chagasi and Leishmania donovani. Serological evaluation revealed that 98% (56 of 57) of Brazilian and 100% (52 of 52) of Sudanese visceral leishmaniasis patients have high antibody levels to the rK39 repeat. Detectable anti-K39 antibody was virtually absent in cutaneous and mucosal leishmaniasis patients and in individuals infected with Trypanosoma cruzi. The data show that rK39 may replace crude parasite antigens as a basis for serological diagnosis of visceral leishmaniasis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Medical Sciences | pt_BR |
dc.source | http://www.pnas.org/content/90/2/775.full.pdf+html | pt_BR |
dc.title | Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis | pt_BR |
dc.title.alternative | Medical Sciences | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 90 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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aaaaaaaaaaaaaaa1525.pdf | 1,27 MB | Adobe PDF | Visualizar/Abrir |
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