Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/12794
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorCosta, Sérgio Ricardo-
dc.contributor.authorD'Oliveira Junior, Argemiro-
dc.contributor.authorBacellar, Maria Olívia Amado Ramos-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.creatorCosta, Sérgio Ricardo-
dc.creatorD'Oliveira Junior, Argemiro-
dc.creatorBacellar, Maria Olívia Amado Ramos-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.date.accessioned2013-09-02T15:33:59Z-
dc.date.available2013-09-02T15:33:59Z-
dc.date.issued1999-
dc.identifier.issn0074-0276-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/12794-
dc.descriptionp. 367-370pt_BR
dc.description.abstractIn areas of Leishmania chagasi transmission the ability to control leishmania infection is associated with IFN-g production. In visceral leishmaniasis down-regulation of T cell responses is mediated by interleukin-10 (IL-10). In this study we evaluated the lymphoproliferative response, IFN-g and IL-10 production on lymphocyte cultures stimulated with recombinant leishmania antigens in subjects with asymptomatic L. chagasi infection. There was a statistically significant difference in the lymphoproliferative response of the subjects with asymptomatic infection as compared to patients with visceral leishmaniasis and healthy subjects with respect to crude antigens (p<0.01), gp-63 (p<0.05) and hsp-70 (p<0.01), as well as between asymptomatic L. chagasi infected subjects and patients with visceral leishmaniasis with respect to the response to all antigens tested. The IFN-g production observed in the group with asymptomatic infection with all the three recombinant antigens tested was higher (p<0.01) than that observed in patients with visceral leishmaniasis and in healthy subjects. Furthermore, in individuals with asymptomatic infection, IL-10 levels in cultures stimulated with recombinant antigens were very low. This study shows that lymphocytes from individuals with asymptomatic L. chagasi infection are able to recognize recombinant leishmania antigens with production of a cytokine that is associated with leishmania killing.pt_BR
dc.language.isoenpt_BR
dc.publisherMemórias do Instituto Oswaldo Cruzpt_BR
dc.sourcehttp://dx.doi.org/10.1590/S0074-02761999000300015pt_BR
dc.subjectAsymptomatic Leishmania chagasi infectionpt_BR
dc.subjectRecombinant leishmania antigenspt_BR
dc.subjectT cell responsespt_BR
dc.titleT Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigenspt_BR
dc.title.alternativeMemórias do Instituto Oswaldo Cruzpt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubRio de janeiropt_BR
dc.identifier.numberv. 94, n. 3pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
5555555555555555555555.pdf95,25 kBAdobe PDFVisualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.