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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/12760
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dc.contributor.authorSchriefer, Nicolaus Albert Borges-
dc.contributor.authorLeopoldo, Paulo T. G.-
dc.contributor.authorMachado, Paulo Roberto Lima-
dc.contributor.authorAlmeida, Roque Pacheco de-
dc.contributor.authorGiudice, Angela-
dc.contributor.authorJesus, Amélia Ribeiro de-
dc.contributor.authorGuimarães, Luiz Henrique-
dc.contributor.authorBacellar, Maria Olívia Amado Ramos-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.creatorSchriefer, Nicolaus Albert Borges-
dc.creatorLeopoldo, Paulo T. G.-
dc.creatorMachado, Paulo Roberto Lima-
dc.creatorAlmeida, Roque Pacheco de-
dc.creatorGiudice, Angela-
dc.creatorJesus, Amélia Ribeiro de-
dc.creatorGuimarães, Luiz Henrique-
dc.creatorBacellar, Maria Olívia Amado Ramos-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.date.accessioned2013-08-27T17:37:57Z-
dc.date.available2013-08-27T17:37:57Z-
dc.date.issued2006-
dc.identifier.issn1471-2334-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/12760-
dc.descriptionp.1-6pt_BR
dc.description.abstractBackground: Disseminated leishmaniasis is an emerging infectious disease, mostly due to L. braziliensis, which has clinical and histopathological features distinct from cutaneous leishmaniasis. Methods: In the current study we evaluated the in vitro production of the cytokines IFN-γ, TNF-α, IL-5 and IL-10 by peripheral blood mononuclear cells (PBMC) from 15 disseminated leishmaniasis and 24 cutaneous leishmaniasis patients upon stimulation with L. braziliensis antigens genotyped as disseminated leishmaniasis or cutaneous leishmaniasis isolates. Results: Regardless of the source of L. braziliensis antigens, PBMC from cutaneous leishmaniasis patients produced significantly higher IFN-γ than PBMC from disseminated leishmaniasis patients. Levels of TNF-α by PBMC from cutaneous leishmaniasis patients were significantly higher than disseminated leishmaniasis patients only when stimulated by genotyped cutaneous leishmaniasis antigens. The levels of IL-5 and IL-10 production by PBMC were very low and similar in PBMCs from both disseminated leishmaniasis and cutaneous leishmaniasis patients. The immune response of each patient evaluated by the two L. braziliensis antigens was assessed in a paired analysis in which we showed that L. braziliensis genotyped as disseminated leishmaniasis isolate was more potent than L. braziliensis genotyped as cutaneous leishmaniasis isolate in triggering IFN-γ and TNF-α production in both diseases and IL-5 only in cutaneous leishmaniasis patients. Conclusion: This study provides evidence that antigens prepared from genotypically distinct strains of L. braziliensis induce different degrees of immune response. It also indicates that both parasite and host play a role in the outcome of L. braziliensis infection.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://dx.doi.org/ doi:10.1186/1471-2334-6-75pt_BR
dc.titleDifferential effects of antigens from L. braziliensis isolates from disseminated and cutaneous leishmaniasis on in vitro cytokine productionpt_BR
dc.title.alternativeBMC Infectious Diseasespt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv.6 n. 75pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (ICS)

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