Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/12746
metadata.dc.type: Artigo de Periódico
Title: Dereplication of bromotyrosine-derived metabolites by LC-PDA-MS and analysis of the chemical profile of 14 aplysina sponge specimens from the Brazilian coastline
Other Titles: Australian Journal of Chemistry
Authors: Silva, Michelli M.
Bergamasco, Juliana
Lira, Simone Possedente de
Lopes, Norberto Peporine
Hajdu, Eduardo
Peixinho, Solange
Berlinck, Roberto Gomes de Souza
metadata.dc.creator: Silva, Michelli M.
Bergamasco, Juliana
Lira, Simone Possedente de
Lopes, Norberto Peporine
Hajdu, Eduardo
Peixinho, Solange
Berlinck, Roberto Gomes de Souza
Abstract: In order to investigate the chemical profile of 14 specimens of Aplysina spp. marine sponges, we have developed a method based on LC-PDA-MS for the detection of bromotyrosine-derived metabolites. The method enabled the dereplication of three distinct chemotypes of bromotyrosine-derived compounds based on UV absorptions, which were further refined by electrospray ionization-mass spectrometry analysis of the brominated quasi-molecular ion clusters. This procedure led to either a single compound assignment, or a maximum of two possible isobaric compounds. The dereplication study indicated that the chemical profile of the 14 specimens of Aplysina spp. analyzed presented practically the same dibromotyrosine-derived compounds. The results obtained suggested a possible biogenetic pathway for the formation of dibromotyrosine-derived compounds of wide occurrence in Verongida sponges.
URI: http://www.repositorio.ufba.br/ri/handle/ri/12746
Issue Date: 2010
Appears in Collections:Artigo Publicado em Periódico (Química)

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