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dc.contributor.authorFreitas, Luiz Antônio Rodrigues de-
dc.contributor.authorSantana, Cláudia Dias de-
dc.contributor.authorVeras, Patrícia Sampaio Tavares-
dc.contributor.authorWelby-Borges, Marcus-
dc.contributor.authorNihei, Jorge S.-
dc.contributor.authorCardillo, Fabíola-
dc.creatorFreitas, Luiz Antônio Rodrigues de-
dc.creatorSantana, Cláudia Dias de-
dc.creatorVeras, Patrícia Sampaio Tavares-
dc.creatorWelby-Borges, Marcus-
dc.creatorNihei, Jorge S.-
dc.creatorCardillo, Fabíola-
dc.descriptionTexto completo: acesso restrito. p.201–205pt_BR
dc.description.abstractCBA/J mice are resistant to Leishmania major and susceptible to Leishmania amazonensis. Early events determine infection outcome. Until now, PIV (in vitro priming) immune response to L. amazonensis has not been assessed. Herein, we have shown that compared to L. major, L. amazonensis induced higher parasite burden associated to similar IL-4, IFN-γ, and TNF-α mRNA expressions and IFN-γ and IL-10 levels. Although similar amounts of IL-10 were detected, the frequency of intracellular IL-10 positive B cells was enhanced in spleen cells stimulated with anti-CD3/anti-CD28, or anti-CD3/anti-CD28 and L. amazonensis, compared to L. major-stimulation. Interestingly, IL-10- producing B cells were reduced in response to anti-CD3/anti-CD28 stimulation combined with L. major compared to the other groups. L. amazonensis may favor T regulatory cell development, since 40% of all the CD4+CD25+ were CD25high cells. These data suggest that in PIV, susceptibility to L. amazonensis is not related to Th cell polarization, but to the presence and activity of regulatory T and B cells.pt_BR
dc.subjectCBA/J micept_BR
dc.subjectLeishmania amazonensispt_BR
dc.subjectLeishmania majorpt_BR
dc.subjectRegulatory T and B cellspt_BR
dc.titleLeishmania amazonensis: Participation of regulatory T and B cells in the in vitro priming (PIV) of CBA/J spleen cells susceptible responsept_BR
dc.title.alternativeExperimental Parasitologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv.113 n. 3pt_BR
Appears in Collections:Artigo Publicado em Periódico Estrangeiro (ISC)

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