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dc.contributor.authorCampos, Gubio Soares-
dc.contributor.authorAngelo, Ana Luiza Dias-
dc.contributor.authorRibeiro, Nadia Regina Caldas-
dc.contributor.authorBraga, Eduardo Lorens-
dc.contributor.authorSantana, Nelma Pereira de-
dc.contributor.authorGomes, Michele Mesquita Soares-
dc.contributor.authorPinho, João Renato Rebello-
dc.contributor.authorCarvalho, Wilson Andrade de-
dc.contributor.authorLyra, Luiz Guilherme Costa-
dc.contributor.authorLyra, André Castro-
dc.creatorCampos, Gubio Soares-
dc.creatorAngelo, Ana Luiza Dias-
dc.creatorRibeiro, Nadia Regina Caldas-
dc.creatorBraga, Eduardo Lorens-
dc.creatorSantana, Nelma Pereira de-
dc.creatorGomes, Michele Mesquita Soares-
dc.creatorPinho, João Renato Rebello-
dc.creatorCarvalho, Wilson Andrade de-
dc.creatorLyra, Luiz Guilherme Costa-
dc.creatorLyra, André Castro-
dc.descriptionTexto completo: acesso restrito. p.636–642pt_BR
dc.description.abstractAbstract: Hepatitis B virus (HBV) can be classified into at least eight genotypes, A–H. We evaluated the distribution HBV genotypes among patients with chronic infection. Methods: We consecutively evaluated adult patients with chronic HBV infection from Salvador, Brazil. Patients were classified according to HBV infection chronic phases based on HBV-DNA levels and presence of serum HBV markers. HBV-DNA was qualitatively and quantitatively detected in serum by polymerised chain reaction (PCR). Isolates were genotyped by comparison of amino acid mutations and phylogenetic analysis. Results: One-hundred and fourteen patients were evaluated. HBV-DNA was positive in 96 samples. HBV genotype was done in 76. Mean age was 36±11.3. In 61 of 76 cases subjects were classified as inactive HBsAg carriers. Their mean HBV serum level was 1760 copies/ml and 53 of 61 were infected with HBV genotype A, seven with HBV genotype F and one with genotype B. Twelve of the 76 patients had detectable hepatitis B e-antigen (HBeAg) in serum. Ten were infected with HBV genotype A and two with genotype F; most had increased alanine aminotransferase and high HBV-DNA levels. Three patients were in the immunotolerant phase, two were infected with HBV genotype A and one with genotype F. HBV subtyping showed subtypes adw2 and adw4. Conclusions: HBV genotype A adw2 and genotype F adw4 were the most prevalent isolates found. We could not find differences in genotype distribution according to HBV clinical phases and DNA levels. We did not detect HBV genotype D in contrast to a previous study in our center with acute hepatitis B. All inactive HBsAg carriers had low HBV-DNA levels.pt_BR
dc.source 10.1111/j.1478-3231.2006.01280.xpt_BR
dc.subjectChronic hepatitis Bpt_BR
dc.subjectHBV genotypept_BR
dc.subjectHepatitis B viruspt_BR
dc.subjectInactive chronic carrierspt_BR
dc.titleDistribution of hepatitis B virus genotypes among patients with chronic infectionpt_BR
dc.title.alternativeLiver Internationalpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 26 n.6pt_BR
Appears in Collections:Artigo Publicado em Periódico Estrangeiro (ISC)

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