https://repositorio.ufba.br/handle/ri/12147
Campo DC | Valor | Idioma |
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dc.contributor.author | Veiga, Patricia C. | - |
dc.contributor.author | Schroth, Robert J. | - |
dc.contributor.author | Guedes, Rosalina | - |
dc.contributor.author | Freire, Songeli Meneses | - |
dc.contributor.author | Nogueira Filho, Getúlio da Rocha | - |
dc.creator | Veiga, Patricia C. | - |
dc.creator | Schroth, Robert J. | - |
dc.creator | Guedes, Rosalina | - |
dc.creator | Freire, Songeli Meneses | - |
dc.creator | Nogueira Filho, Getúlio da Rocha | - |
dc.date.accessioned | 2013-07-09T12:56:11Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/12147 | - |
dc.description | Texto completo. Acesso restrito. p. 505–510 | pt_BR |
dc.description.abstract | Objective: The aim of this study was to evaluate possible immunologic relationships between sickle cell anaemia (SCA) and periodontal inflammation and its impact on serum cytokines. Design: Twenty-five Brazilian children of African descent were involved in this study and divided in two groups: SCA (n = 10): confirmed diagnosis of homozygous anaemia; and CTR-control (n = 15): no sickle anaemia. Clinical examination included comprehensive medical (routine physical evaluation) and periodontal exams: plaque index (PI), bleeding on probing (BoP), and haematological analysis. Serum samples were collected for cytokine evaluation by microarray. Clinical and laboratorial parameters were compared statistically (alpha = 5%). Results: The higher values of PI and BoP were similar for both groups ( p > 0.05) confirming a diagnosis of generalized gingivitis for all individuals. Intergroup analysis showed higher levels of interferon gamma (IFNg), tumour necrosis alpha (TNFa), interleukin (IL)-4, -5, -8, -10 and 13 only in the SCA group ( p < 0.05). In addition, PI was negatively correlated with IL-2, IL-4, IL-5, IL-6, IL-8 and IL-13, while BoP was positively correlated with IL-10. Conclusion: Within the limits of the present study, it was concluded that SCA increase the levels of serum cytokines regardless of the presence of periodontal inflammation. Therefore, a direct immunological relationship between SCA and periodontal inflammation was not established. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Archives of Oral Biology | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.archoralbio.2012.11.006 | pt_BR |
dc.subject | Sickle cell anaemia | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | Gingivitis | pt_BR |
dc.subject | Inflammation | pt_BR |
dc.subject | African descent | pt_BR |
dc.title | Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia | pt_BR |
dc.title.alternative | Archives of Oral Biology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 58, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
Arquivo | Descrição | Tamanho | Formato | |
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7777777777.pdf Restricted Access | 279,26 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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