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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/12073
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dc.contributor.authorHuang, Lili-
dc.contributor.authorGao, Li-
dc.contributor.authorFigueiredo, Camila-
dc.contributor.authorRafaels, Nicholas M.-
dc.contributor.authorVergara, Candelaria I.-
dc.contributor.authorRuczinski, Ingo-
dc.contributor.authorBeaty, Terri H.-
dc.contributor.authorBarnes, Kathleen C.-
dc.contributor.authorMathias, Rasika A.-
dc.creatorHuang, Lili-
dc.creatorGao, Li-
dc.creatorFigueiredo, Camila-
dc.creatorRafaels, Nicholas M.-
dc.creatorVergara, Candelaria I.-
dc.creatorRuczinski, Ingo-
dc.creatorBeaty, Terri H.-
dc.creatorBarnes, Kathleen C.-
dc.creatorMathias, Rasika A.-
dc.date.accessioned2013-07-03T16:50:09Z-
dc.date.available2013-07-03T16:50:09Z-
dc.date.issued2013-
dc.identifier.issn0091-6749-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/12073-
dc.descriptionTexto completo. Acesso restrito. p. 53pt_BR
dc.description.abstractRationale ST2 (IL1RL1), is an IL1 family receptor that mediates important effectors of Th2 functions. Its soluble form (sST2) neutralizes its ligand, IL-33, by acting as a decoy receptor. Serum sST2 has been used as a biomarker for disease severity and outcome for multiple inflammatory and lung diseases, including atopic asthma. We undertook a targeted deep resequencing of ST2 gene in 241 samples of African ancestry to identify ST2variants controlling serum sST2 levels. Methods Serum sST2 concentration was measured by ELISA, and resequencing of ∼50kb (chr2:102922962-102973497) encompassing the ST2gene was performed using Illumina's HiSeq2000. Single-variant tests for all common variants (MAF≥5%) were performed using linear regression assuming an additive model on log serum total ST2 considering age, gender and the first two principal components on a pre-existing genome-wide association panel of ancestry informative markers to adjust for admixture. Results A total of 565 ST2 variants were identified, 192 of which had a MAF≥5% including 3 coding synonymous and 6 missense variants. In the sST2 level analysis, ten SNPs in strong linkage disequilibrium yielded p-value less than 10-3; a single common haplotype (frequency=65%) across all 10 SNPs yielded an overall p-value = 0.0002 and was negatively associated with sST2 levels (β = -0.09). Conclusions Sequencing ST2 gene revealed a novel haplotype influencing sST2 levels in individuals of African ancestry, including 5 variants mapping to intron 1 and 5 mapping to the 5’ region of ST2. Further work is ongoing to fully explore this association in an additional 400 subjects of African ancestry.pt_BR
dc.language.isoenpt_BR
dc.publisherJournal of Allergy and Clinical Immunologypt_BR
dc.sourcehttp://dx.doi.org/10.1016/j.jaci.2012.12.873pt_BR
dc.titleSequencing of the ST2 Gene Reveals a Haplotype That Determines Serum Total ST2 Levels in Individuals of African Ancestrypt_BR
dc.title.alternativeJournal of Allergy and Clinical Immunologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubSalvadorpt_BR
dc.identifier.numberv. 131, n. 2pt_BR
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