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metadata.dc.type: | Artigo de Periódico |
Title: | Severe asthma associated with myasthenia gravis and upper airway obstruction |
Other Titles: | Journal of Investigational Allergology and Clinical Immunology |
Authors: | Machado, Adelmir de Souza Ponte, Eduardo Vieira Cruz Filho, Álvaro Augusto Souza da |
metadata.dc.creator: | Machado, Adelmir de Souza Ponte, Eduardo Vieira Cruz Filho, Álvaro Augusto Souza da |
Abstract: | An unusual association of asthma and myasthenia gravis (MG) complicated by tracheal stenosis is reported. The patient was a 35-year-old black woman with a history of severe asthma and rhinitis over 30 years. A respiratory tract infection triggered a life-threatening asthma attack whose treatment required orotracheal intubation and mechanical ventilatory support. A few weeks later, tracheal stenosis was diagnosed. Clinical manifestations of MG presented 3 years after her near-fatal asthma attack. Spirometry showed severe obstruction with no response after inhalation of 400 μg of albuterol. Baseline lung function parameters were forced vital capacity, 3.29 L (105% predicted); forced expiratory volume in 1 second (FEV1), 1.10 L (41% predicted); maximal midexpiratory flow rate, 0.81 L/min (26% predicted). FEV1 after administration of albuterol was 0.87 L (32% predicted). The patient's flow-volume loops showed flattened inspiratory and expiratory limbs, consistent with fixed extrathoracic airway obstruction. Chest computed tomography scans showed severe concentric reduction of the lumen of the upper thoracic trachea. © 2007 Esmon Publicidad. |
Keywords: | Asthma Exacerbation Myasthenia gravis Tracheal stenosis |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15947 |
Issue Date: | 2007 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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