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https://repositorio.ufba.br/handle/ri/15036
metadata.dc.type: | Artigo de Periódico |
Título : | Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults |
Otros títulos : | Arquivos brasileiros de Endocrinologia e Metabologia |
Autor : | Mello, Adriana Lima Cunha, Selma Freire de Carvalho da Freitas, Maria Cristina Foss Vannucchi, Helio |
metadata.dc.creator: | Mello, Adriana Lima Cunha, Selma Freire de Carvalho da Freitas, Maria Cristina Foss Vannucchi, Helio |
Resumen : | OBJECTIVE: To determine plasma homocysteine levels during fasting and after methionine overload, and to correlate homocysteinemia according to methylenetetrahydrofolate reductase (MTHFR) polymorphism in type 2 diabetic adults. SUBJECTS AND METHODS: The study included 50 type 2 diabetic adults (DM group) and 52 healthy subjects (Control group). Anthropometric data, and information on food intake, serum levels of vitamin B12, folic acid and plasma homocysteine were obtained. The identification of C677T and A1298C polymorphisms was carried out in the MTHFR gene. RESULTS: There was no significant difference in homocysteinemia between the two groups, and hyperhomocysteinemia during fasting occurred in 40% of the diabetic patients and in 23% of the controls. For the same polymorphism, there was not any significant difference in homocysteine between the groups. In the Control group, homocysteinemia was greater in those subjects with C677T and A1298C polymorphisms. Among diabetic subjects, those with the A1298C polymorphism had lower levels of homocysteine compared with individuals with C677T polymorphism. CONCLUSION:The MTHFR polymorphism (C677T and A1298C) resulted in different outcomes regarding homocysteinemia among individuals of each group (diabetic and control). These data suggest that metabolic factors inherent to diabetes influence homocysteine metabolism. |
Palabras clave : | Diabetes Homocysteine Methylenetetrahydrofolate reductase Polymorphism Diabetes Mellitus, Type 2 Methionine Methylenetetrahydrofolate Dehydrogenase (NADP) Cystathionine Hyperhomocysteinemia |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/15036 |
Fecha de publicación : | 2012 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Escola de Nutrição) |
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