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https://repositorio.ufba.br/handle/ri/14766
metadata.dc.type: | Artigo de Periódico |
Title: | Composição química e atividade anticolinesterásica de uma fração ativa do extrato de folhas de Citrus limon (L.) Burm |
Other Titles: | Química Nova |
Authors: | Carvalho, Rusbene Bruno Fonseca de Almeida, Antonia Amanda Cardoso de Freitas, Rivelilson Mendes de Lima, Luciano Silva David, Juceni Pereira de Lima David, Jorge Mauricio Feitosa, Chistiane Mendes |
metadata.dc.creator: | Carvalho, Rusbene Bruno Fonseca de Almeida, Antonia Amanda Cardoso de Freitas, Rivelilson Mendes de Lima, Luciano Silva David, Juceni Pereira de Lima David, Jorge Mauricio Feitosa, Chistiane Mendes |
Abstract: | This paper describes the chemical composition and acetylcholinesterase inhibition of an active chromatographic fraction of the EtOAc extract of Citrus limon leaves. The composition of the active fraction presented a mixture of two coumarins, 5,8-dimethoxy-psoralen and 5,7- dimethoxycoumarin, identified by ¹H and ¹³C NMR data analysis, including DEPT, COSY, HMBC and HSQC experiments. It was also demonstrated that this mixture presents qualitative and quantitative AChE inhibition. In vitro studies indicated a CE50 value of 340 µg/mL with 95% of confidence. In vivo studies (10 and 25 mg/kg) revealed inhibition of 30.09 and 30.06% of AChE activity in relation to neostigmine, respectively. |
Keywords: | Citrus limon (L.) Burm Psoraleno Acetylcholinesterase |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14766 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
Files in This Item:
File | Description | Size | Format | |
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0100-40422013000900017.pdf | 145,14 kB | Adobe PDF | View/Open |
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