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https://repositorio.ufba.br/handle/ri/14282
metadata.dc.type: | Artigo de Periódico |
Título : | Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
Otros títulos : | Journal of Infectious Diseases |
Autor : | Santos, Silvane Maria Braga Rodrigues Junior, Waldyr Muniz, André Luís Nunes Basílio, Vanessa Neva, Franklin A. Dutra, Walderez Ornelas Gollob, Kenneth John Jacobson, Steven Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Santos, Silvane Maria Braga Rodrigues Junior, Waldyr Muniz, André Luís Nunes Basílio, Vanessa Neva, Franklin A. Dutra, Walderez Ornelas Gollob, Kenneth John Jacobson, Steven Carvalho Filho, Edgar Marcelino de |
Resumen : | Human T cell lymphotropic virus type 1 (HTLV-1) infection is associated with an exacerbated type 1 immune response and secretion of high levels of proinflammatory cytokines. In contrast, helminthic infection induces a type 2 immune response. In the present study, the cytokine profile in HTLV-1 carriers coinfected with helminths (Strongyloides stercoralis and/or Schistosoma mansoni) was compared with that in HTLV-1 carriers not coinfected with helminths. Levels of interferon (IFN)-γ were higher in HTLV-1 carriers not coinfected with helminths than in HTLV-1 carriers coinfected with helminths (P < .05). The overall frequency of IFN-γ-expressing CD8+ and CD4+ cells was decreased in HTLV-1 carriers coinfected with helminths (P > .05). The percentage of interleukin (IL)-5- and IL-10-expressing T cells in HTLV-1 carriers coinfected with helminths was higher than that in HTLV-1 carriers not coinfected with helminths (P < .05). Moreover, we found that the prevalence of helminthic infection was 7-fold higher in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (P < .05). These data show that helminthic infection decreases activation of type 1 cells, which may influence the clinical outcome of HTLV-1 infection. |
Palabras clave : | Human T-lymphotropic virus 1 CD4-Positive T-Lymphocytes Myelitis Paraparesis Tropical Spastic |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/14282 |
Fecha de publicación : | 2005 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Silvane B. Santos.pdf | 425,47 kB | Adobe PDF | Visualizar/Abrir |
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