Síndrome Metabólica, Seus Fenótipos e Resistência à Insulina pelo HOMA-RI

Abstract

Metabolic Syndrome, Its Phenotypes, and Insulin Resistance by HOMA-IR. The diagnosis of the metabolic syndrome (MS) according to the National Cholesterol Education Program Adult Treatment Panel III does not reflect necessarily the presence of insulin resistance (IR), a potential therapeutical target for type 2 diabetes and cardiovascular disease prevention. Based on previous prevalence data, a cross-sectional study was conducted to determine the HOMA-IR relationship to the MS and some associated abnormalities. HOMA-IR was higher in individuals with the MS (2.8 ± 1.6 vs. 1.8 ± 1.4) (p < 0.001). HOMA-IR ≥ 2.5 allied good specificity and sensitivity levels for the association of MS and IR. Hyperglycemia, hypertrigliceridemia, and abdominal obesity, the MS components best related to IR, were statistically associated with HOMA-IR ≥ 2.5, but not hypertension neither low HDL-c. The demonstration that some of MS phenotypes or associated abnormalities were more predictive for IR could point out to the possibility of the use of the index as a marker of the presence of IR associated to MS. (Arq Bras Endocrinol Metab 2007;51/9:1506-1515)