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metadata.dc.type: | Artigo de Periódico |
Título : | Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model |
Otros títulos : | Memórias do Instituto Oswaldo Cruz |
Autor : | Souza, Marcia Maria de Paraná, Raymundo Trepo, Christian Barbosa Júnior, Aryon de Almeida Oliveira, Irismar Andrade, Zilton de Araújo |
metadata.dc.creator: | Souza, Marcia Maria de Paraná, Raymundo Trepo, Christian Barbosa Júnior, Aryon de Almeida Oliveira, Irismar Andrade, Zilton de Araújo |
Resumen : | Interferon-a is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-a proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-a on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed. |
Palabras clave : | Interferon-a Hepatic fibrosis Capillaria hepatica Capillaria Interferons Hepatitis B Hepatitis C Hydroxyproline |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/15059 |
Fecha de publicación : | 2001 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Marcia Maria de Souza.pdf | 261,86 kB | Adobe PDF | Visualizar/Abrir |
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