Resumo:
Segmental and focal glomerulosclerosis not otherwise specified (FSGS NOS) is a
glomerulopathy with undefined outcome. We reviewed possible histopathological markers of
chronicity from the literature and identified 33 cases of FSGS NOS for our sample. Based on
the frequency of certain markers, we developed an experimental scoring system that uses
tubular atrophy, interstitial fibrosis, glomerular hyalinosis, arteriolosclerosis, and glomerular
sclerosis. We applied an experimental scoring system to predict chronicity. Our analysis
revealed a sensitivity of 0.66 and a specificity of 0.80. Glomerular hyalinosis emerged as the
most reliable isolated parameter, with a sensitivity of 0.83 and a specificity of 0.70. We obtained
a survey of risk mutation of APOL1 genes from 25 of 33 patients. Additionally, we conducted
our specimen in scanning for future endeavors in digital pathology for AI training.
