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Análise comparativa do perfil imunológico e bioquímico entre pacientes com Doença Pulmonar Obstrutiva Crônica e pacientes com Espirometria com Comprometimento da Relação Preservada (PRISm)
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| dc.creator | Braz, Leticia Helen Dias | |
| dc.date.accessioned | 2026-02-04T16:40:26Z | |
| dc.date.available | 2026-02-04T16:40:26Z | |
| dc.date.issued | 2026-12-03 | |
| dc.identifier.citation | BRAZ, Leticia Helen Dias. Análise comparativa do perfil imunológico e bioquímico entre pacientes com doença pulmonar obstrutiva crônica e pacientes com espirometria com comprometimento da relação preservada (PRISm). Orientadora: Gyselle Chrystina Baccan; Coorientadora: Margarida Célia Lima Costa Neves. 2025. 77 f. Dissertação (Mestrado em Imunologia) - Universidade Federal da Bahia, Instituto de Ciências da Saúde, Salvador, 2025. | pt_BR |
| dc.identifier.uri | https://repositorio.ufba.br/handle/ri/43990 | |
| dc.description.abstract | Chronic Obstructive Pulmonary Disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) are pulmonary conditions that share common factors. However, the pathophysiological mechanisms differentiating these entities remain poorly understood. This study aimed to compare the immunological and biochemical profiles of patients with COPD and PRISm and to analyze the correlation of these biomarkers with anthropometric parameters in each group. A cross-sectional analytical study was conducted involving 72 patients aged 50-80 years. Serum cytokines (IL-6, IL-8, IL-10, IL-12, TNF), biochemical markers (total cholesterol, HDL, LDL, triglycerides, glucose, glycated hemoglobin), and anthropometric measurements (waist circumference, triceps skinfold thickness, mid upper arm circumference) were assessed. No statistically significant differences were found between the groups regarding cytokine or biochemical levels. However, in COPD patients, abdominal circumference correlated positively with IL-6 levels (r = 0.565; p < 0.05), while triceps skinfold thickness showed a significant inverse correlation with IL-10 (r = – 0.427; p < 0.05). In PRISm patients, glucose levels were positively correlated with mid upper arm circumference (r = 0.574; p < 0.05) and body mass index (r = 0.567; p < 0.05). Although COPD and PRISm patients exhibited similar inflammatory and biochemical profiles, our analysis of correlations with body composition parameters showed distinct associations. The presents findings underscore the importance of individualized clinical management for each patient group. | pt_BR |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt_BR |
| dc.language | por | pt_BR |
| dc.publisher | Universidade Federal da Bahia | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Doença Pulmonar Obstrutiva Crônica (DPOC) | pt_BR |
| dc.subject | Espirometria com Comprometimento da Relação Preservada (PRISm) | pt_BR |
| dc.subject | Citocinas | pt_BR |
| dc.subject | Perfil metabólico | pt_BR |
| dc.subject | Antropometria | pt_BR |
| dc.subject | Inflamação | pt_BR |
| dc.subject.other | chronic obstructive pulmonary disease (COPD) | pt_BR |
| dc.subject.other | Preserved Ratio Impaired Spirometry (PRISm) | pt_BR |
| dc.subject.other | cytokines | pt_BR |
| dc.subject.other | Metabolic profile | pt_BR |
| dc.subject.other | anthropometry | pt_BR |
| dc.subject.other | inflammation | pt_BR |
| dc.title | Análise comparativa do perfil imunológico e bioquímico entre pacientes com Doença Pulmonar Obstrutiva Crônica e pacientes com Espirometria com Comprometimento da Relação Preservada (PRISm) | pt_BR |
| dc.title.alternative | Comparative Analysis of Immunological and Biochemical Patient Profiles in Chronic Obstructive Pulmonary Disease and Preserved Ratio Impaired Spirometry (PRISm) | pt_BR |
| dc.type | Dissertação | pt_BR |
| dc.publisher.program | Programa de Pós-Graduação em Imunologia - (PPGIM) | pt_BR |
| dc.publisher.initials | UFBA | pt_BR |
| dc.publisher.country | Brasil | pt_BR |
| dc.subject.cnpq | CNPQ::CIENCIAS DA SAUDE | pt_BR |
| dc.contributor.advisor1 | Baccan, Gyselle Chrystina | |
| dc.contributor.advisor1ID | https://orcid.org/0000-0001-8479-508X | pt_BR |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/1780475016440250 | pt_BR |
| dc.contributor.advisor-co1 | Neves, Margarida Célia Lima Costa | |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/2617272725974050 | pt_BR |
| dc.contributor.referee1 | Baccan, Gyselle Chrystina | |
| dc.contributor.referee1ID | https://orcid.org/0000-0001-8479-508X | pt_BR |
| dc.contributor.referee1Lattes | http://lattes.cnpq.br/1780475016440250 | pt_BR |
| dc.contributor.referee2 | Macambira, Simone Garcia | |
| dc.contributor.referee2Lattes | http://lattes.cnpq.br/0000934973237500 | pt_BR |
| dc.contributor.referee3 | Medeiros, Jairza Maria Barreto | |
| dc.contributor.referee3Lattes | http://lattes.cnpq.br/6674302443921098 | pt_BR |
| dc.creator.ID | https://orcid.org/0009-0001-8322-3394 | pt_BR |
| dc.creator.Lattes | http://lattes.cnpq.br/4025484523751262 | pt_BR |
| dc.description.resumo | A Doença Pulmonar Obstrutiva Crônica (DPOC) e a Espirometria com Comprometimento da Relação Preservada (PRISm) compartilham fatores de risco. No entanto, os mecanismos fisiopatológicos que diferenciam ambas as condições ainda são pouco compreendidas. Este estudo teve como objetivo comparar os perfis imunológicos e bioquímicos de pacientes com DPOC e PRISm e analisar a correlação desses biomarcadores com parâmetros antropométricos em cada grupo. Foi realizado um estudo analítico transversal envolvendo 72 pacientes com idades entre 50 e 80 anos. Foram avaliadas citocinas séricas (IL-6, IL-8, IL-10, IL-12 e TNF), marcadores bioquímicos (colesterol total, HDL, LDL, triglicerídeos, glicose e hemoglobina glicada) e medidas antropométricas (circunferência abdominal, dobra cutânea tricipital e circunferência do braço). Não foram encontradas diferenças estatisticamente significativas entre os grupos em relação aos níveis de citocinas ou bioquímicos. No entanto, em pacientes com DPOC, a circunferência abdominal apresentou correlação positiva com os níveis de IL-6 (r = 0,565; p < 0,05), enquanto a espessura da prega cutânea tricipital mostrou correlação inversa significativa com a IL-10 (r = –0,427; p < 0,05). Em pacientes com PRISm, os níveis de glicose apresentaram correlação positiva com a circunferência do braço (r = 0,574; p < 0,05) e com o índice de massa corporal (r = 0,567; p < 0,05). Embora os pacientes com DPOC e PRISm apresentassem perfis inflamatórios e bioquímicos semelhantes, nossa análise de correlações com parâmetros de composição corporal mostrou associações distintas. Os presentes achados ressaltam a importância do manejo clínico individualizado para cada grupo de pacientes. | pt_BR |
| dc.publisher.department | Instituto de Ciências da Saúde - ICS | pt_BR |
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Independent effect of the triglyceride-glucose index on all-cause mortality in critically ill patients with chronic obstructive pulmonary disease and asthma: A retrospective cohort study. Chronic Respiratory Disease, 21. https://doi.org/10.1177/14799731241245424 | pt_BR |
| dc.type.degree | Mestrado Acadêmico | pt_BR |
