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Ancestralidade como fator de risco para hipotireoidismo: estudo da coorte ELSA-BRASIL
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| dc.creator | MARTINS, DIANA VIEGAS | |
| dc.date.accessioned | 2025-08-01T14:02:29Z | |
| dc.date.available | 2025-08-01T14:02:29Z | |
| dc.date.issued | 2025-02-17 | |
| dc.identifier.citation | Martins, Diana Viegas Ancestralidade como fator de risco para hipotireoidismo: estudo da coorte ELSA-BRASIL / [Manuscrito]. Diana Viegas Martins. Salvador, 2024. 63 f.: il. | pt_BR |
| dc.identifier.uri | https://repositorio.ufba.br/handle/ri/42653 | |
| dc.description.abstract | Introduction– Genomic ancestry refers to the genetic relationship between an individual and their ancestors, from whom they biologically descend. The self-reported ancestry of the Brazilian population is subject to important genomic divergence and there are sensitive markers capable of stratifying the three main Brazilian ancestral roots. The prevalence of hypothyroidism in Brazil is approximately 7.4% and has been highlighted as possibly one of the highest in the world. The ELSA-Brazil-thyroid study showed that women self-reported as white have a higher frequency of hypothyroidism than brown and black women. Objective – To determine genomic ancestry as a risk factor for hypothyroidism. Material and methods – 9372 participants (53.8% women; average age 51 years) from the ELSA-Brazil study cohort were included. Purified DNA was obtained from participants' peripheral blood using the QIAamp DNA Mini-kit1. Samples were genotyped using a panel of 192 ancestry-informative markers. Genomic ancestry analysis was conducted using the ADMIXTURE program. Results – The prevalence of subclinical hypothyroidism (SCH) and clinical hypothyroidism (CH) was found to be 9% and 7.1%, respectively; Female sex increased the risk of CH by 4.43 and 4.68, respectively, in univariate and multivariate logistic regression analyses. Regarding predominant genomic ancestry, genotyping divided individuals into 69.9% with European predominance (EUR), 13% African (AFR), 4.6% native and 12.5% with multiancestry genotype. The EUR subgroup had the highest prevalence of CH (7.9%), demonstrating that EUR ancestry is associated with a higher risk of CH while African genomic ancestry (AFR) and multiancestry played a protective role. On the other hand, the predominant AFR genomic ancestry had the highest percentage of hyperthyroidism (1.7%). Obesity increased the risk of CH and the percentage of hypertension, diabetes mellitus and obesity were significantly higher in the predominant AFR genomic ancestry subgroup. TSH demonstrated a directly proportional relationship with EUR ancestry (p < 0.01) and inversely proportional relationship with AFR (p < 0.01), as well as with free T4 (p < 0.01). Conclusion – Our results demonstrate the important influence of ancestry on thyroid diseases and associated diseases. | pt_BR |
| dc.language | por | pt_BR |
| dc.publisher | Universidade Federal da Bahia | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Glândula Tireoide | pt_BR |
| dc.subject | Hipotireoidismo | pt_BR |
| dc.subject | Hyperthyroidism | pt_BR |
| dc.subject | Ancestralidade | pt_BR |
| dc.subject | Estudo ELSA-Brasil | pt_BR |
| dc.subject.other | Thyroid Gland | pt_BR |
| dc.subject.other | Hypothyroidism | pt_BR |
| dc.subject.other | hyperthyroidism | pt_BR |
| dc.subject.other | ancestry | pt_BR |
| dc.subject.other | Elsa-Brazil study | pt_BR |
| dc.title | Ancestralidade como fator de risco para hipotireoidismo: estudo da coorte ELSA-BRASIL | pt_BR |
| dc.title.alternative | Genomic ancestry as a risk factor for hypothyroidism: ELSA-Brazil cohort study | pt_BR |
| dc.type | Dissertação | pt_BR |
| dc.publisher.program | Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGORGSISTEM) | pt_BR |
| dc.publisher.initials | UFBA | pt_BR |
| dc.publisher.country | Brasil | pt_BR |
| dc.subject.cnpq | CNPQ::CIENCIAS DA SAUDE | pt_BR |
| dc.contributor.advisor1 | Ramos, Helton Estrela | |
| dc.contributor.advisor1ID | https://orcid.org/0000-0002-2900-2099 | pt_BR |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/5624505454133902 | pt_BR |
| dc.contributor.advisor-co1 | Beltrão, Fabyan Esberard de Lima | |
| dc.contributor.advisor-co1ID | https://orcid.org/0000-0001-9713-2584 | pt_BR |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/5497252471759346 | pt_BR |
| dc.contributor.referee1 | Toralles, Maria Betânia Pereira Toralles | |
| dc.contributor.referee1ID | https://orcid.org/0000-0001-7970-7102 | pt_BR |
| dc.contributor.referee1Lattes | http://lattes.cnpq.br/7880272950478674 | pt_BR |
| dc.contributor.referee2 | Ward, Laura Sterian | |
| dc.contributor.referee2ID | https://orcid.org/0000-0003-1601-3220 | pt_BR |
| dc.contributor.referee2Lattes | http://lattes.cnpq.br/5673229011742456 | pt_BR |
| dc.contributor.referee3 | Ramos, Helton Estrela | |
| dc.contributor.referee3ID | https://orcid.org/0000-0002-2900-2099 | pt_BR |
| dc.contributor.referee3Lattes | http://lattes.cnpq.br/5624505454133902 | pt_BR |
| dc.creator.ID | 0000-0002-2111-2664 | pt_BR |
| dc.creator.Lattes | http://lattes.cnpq.br/9777958938529880 | pt_BR |
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| dc.description.resumo | Introdução – A expressão ancestralidade genômica se refere à relação genética entre um indivíduo e seus ancestrais, dos quais descende biologicamente. A ancestralidade autorreferida da população brasileira está sujeita a importante divergência da ancestralidade genômica, e existem marcadores sensíveis e capazes de estratificar as três principais raízes ancestrais brasileiras. A prevalência de hipotireoidismo no Brasil é de aproximadamente 7,4% e ela tem sido destacada como possivelmente umas das maiores do mundo. O estudo Elsa Brasil tireoide evidenciou que mulheres autorreferidas como brancas apresentam uma frequência maior de hipotireoidismo do que pardas e negras. Objetivo – Determinar a ancestralidade genômica como fator de risco para hipotireoidismo. Material e métodos – Foram incluídos 9.372 participantes, 53,8% do sexo feminino, com idade média de 51 anos, da coorte do estudo Elsa-Brasil. O DNA purificado foi obtido do sangue periférico dos participantes, usando-se o QIAamp DNA Mini-kit1. As amostras foram genotipadas usando se um painel 192 marcadores informativos de ancestralidade. A análise da ancestralidade genômica foi conduzida com o uso do programa Admixture. Resultados – A prevalência de hipotireoidismo subclínico (HSC) e hipotireoidismo clínico (HC) encontrada foi de 9% e 7,1%, respectivamente; ser do sexo feminino aumentou o risco de HC em 4,43 e 4,68, respectivamente, nas análises de regressão logística univariada e multivariada. Sobre a ancestralidade genômica predominante, a genotipagem classificou os indivíduos em: 69,9% com predominância europeia (EUR); 13% africana (AFR); 4,6% nativa; e 12,5% com genótipo de multiancestralidade. O subgrupo EUR teve a maior prevalência de HC (7,9%), demonstrando que a ancestralidade EUR está associada a um maior risco de HC, enquanto as ancestralidades genômicas africana (AFR) e a multiancestralidade tiveram papel protetor. Por outro lado, a ancestralidade genômica predominantemente AFR teve o maior percentual de hipertireoidismo (1,7%). A obesidade aumentou o risco de HC, e o percentual de hipertensão arterial, diabetes mellitus e obesidade foi significativamente mais elevado no subgrupo de ancestralidade genômica predominantemente AFR. O TSH demonstrou relação diretamente proporcional com a ancestralidade EUR (p < 0,01) e inversamente proporcional com a AFR (p < 0,01), assim como com o T4 livre (p < 0,01). Conclusão – Nossos resultados demonstram a importante influência da ancestralidade nas doenças tireoidianas e doenças associadas. | pt_BR |
| dc.publisher.department | Instituto de Ciências da Saúde - ICS | pt_BR |
| dc.type.degree | Mestrado Acadêmico | pt_BR |
