Resumo:
COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS
CoV-2), has caused numerous clinical manifestations that can lead to death. In a short
period of time, the disease spread globally, mainly affecting individuals with comorbidities
such as hypertension and diabetes. Studies demonstrate the participation of the
individual's immune system in the patient's clinical evolution as well as its outcome and,
therefore, the study addresses the role of certain cytokines in regulating the immune
response and the comparison between them. This is a cross-sectional study, approved by
the National Research Ethics Commission (CONEP) and aimed to evaluate the serum
levels of Th1 response cytokines (IL-2, IL-12, INF-y and TNF-a) hospitalized. in serious
condition in an intensive care unit at the Hospital Geral of Vitória da Conquista in state of
Bahia. The study was carried out on 56 patients with an average of 64 years old, ranging
between 16 and 97 years old, with the majority of patients being female (58.3) and, as a
result, it was applied that plasma concentrations of IL-2 and INF -y are present in patients
affected by COVID-19 in serious condition.
