Saúde muscular em pacientes portadores de doença renal crônica não dialítica: marcadores clínicos nutricionais e de qualidade de vida

Abstract

The progression of chronic kidney disease is accompanied by multiple nutritional and metabolic abnormalities, which can compromise renal function, affecting the clinical and nutritional status of these patients. Among the nutritional alterations, sarcopenia and dynapenia stand out, terms used to designate a reduction in muscle mass, muscle strength and physical performance. OBJECTIVES: To identify the association of muscle quality markers with clinical, nutritional and quality of life aspects in patients with non-dialytic chronic kidney disease. METHODS: This is a cross-sectional study conducted from January to September 2012 with patients with CKD stages 3 to 5 (stage 5 non-dialysis) who were followed at the Nutrition and Nephropathy Outpatient Clinic of the Professor Francisco de Magalhães Neto Outpatient Clinic. Adult patients (20 and <60 years) and elderly patients (≥60 years), of both sexes, with creatinine clearance between 89 and 15 ml/min/1.73m², participated in this study. Anthropometric, body composition, muscle strength, biochemical and quality of life indicators were evaluated. RESULTS: The results presented allow us to conclude that sarcopenia and dynapenia are prevalent in patients with CKD-ND and that, according to the review performed, they are prognostic of severity, including mortality. It is worth noting that muscle health indicators were associated with quality of life domains related to physical health in this population. In addition, it was observed that the phase angle and HGS measurement can be indicators to assess muscle quality in these patients. CONCLUSION: our studies reinforce the importance of monitoring nutritional indicators associated with muscle quality in order to reduce possible clinical and nutritional complications and the impact on quality of life in patients with non-dialysis-dependent chronic kidney disease.