Variáveis clínicas que interferem na concentração plaquetária do Plasma Rico em Plaquetas (PRP)

Abstract

Tissue regeneration is studied a lot within the scientific community and therapeutic options for this, minimally invasive, gain prominence, as they involve much lower intra and postoperative invasive procedures for the patient compared to surgical procedures of great extension. To this end, the autologous biological compound platelet-rich plasma (PRP) becomes a path towards the objective of regenerating an injury at the rate that it delivers to the patient a supraphysiological concentration of cellular mediators found within platelets, active in the inflammatory process, including growth factors and cytokines. The composition of the bioproduct will be influenced by the baseline health of the individual for whom the PRP is being prepared, consequently affecting the development of the therapy. The present work explores some clinical variables that may affect the platelet concentration of the bioproduct by analyzing them using the Poisson distribution, considering studying the relationship between the variable D and PRL with the variables: 𝑋1 = group (1-presence of osteoarthritis; 0- no presence of osteoarthritis); 𝑋2 = gender (1- masculine; 0- feminine); 𝑋3 = age (1- under 60 years old; 0- over 60 years old); 𝑋4 = smoker (1-yes; 0-no); 𝑋5 = alcohol consumption (1-yes; 0-no); 𝑋6 = Frequency of non-steroid anti-inflammatory consumption (NSAIDs) (1- diary; 2- casually; 3- don't use); 𝑋7 = presence of self-reported diabetes (1-yes; 0-no); 𝑋8 = presence of self-reported hypertension (1-yes; 0-no); 𝑋9 = presence of osteoarticular and/or musculoskeletal conditions (1-yes; 0-no). With the exception of the variable gender and frequency of occasional NSAID consumption, the variables had a significant impact on platelet concentration and difference in platelet-rich plasma. Therefore, when determining the production of the biomaterial, it is necessary to give importance and consider the clinical aspects of the patient's health status, observing and analyzing the variables portrayed, since this immunological profile of the patient will also be exposed in the platelet concentrate produced and this will interfere with the therapeutic quality and the desired recovery process.