AVALIAÇÃO DO OSSO TRABECULAR E CORTICAL DA MANDÍBULA DE PACIENTES ONCOLÓGICOS EM USO DE MEDICAMENTOS ANTIRREABSORTIVOS

Abstract

Abstract: Purpose: To evaluate the changes and complexity of bone trabeculae of the jaw in individuals with cancer who were or were not using antiresorptive drugs through panoramic morphometric indices and fractal dimensions (FDs). Methods: This was a retrospective study that analyzed clinical records and panoramic radiographs of individuals with cancer. The risk group (RG) consists of 22 individuals using zoledronic acid (ZA) or denosumab for a minimum period of 12 months. The control group (CG) consisted of 26 individuals without a history of the use of any antiresorptive drugs. Linear measurements were performed to obtain the panoramic radiomorphometric indices and the FD in four different regions of interest (ROIs). Results: In the RG, 72.7% of the patients were using ZA, while 27.3% were using denosumab. Death was confirmed in 36.3% of RG patients, all due to cancer (p = 0.004). In the FD analysis, the ROIs of the mandibular angle (p = 0.000) and premolar region (p = 0.005) of the RG showed significant changes in bone complexity when compared to the CG. In the analysis of panoramic radiomorphometric indices, the mental index showed a significant increase in linear measurements of the RG when compared to the CG (p = 0.008). 25 Conclusions: The FD analysis of the mandibular angle and premolar angle regions of the RG showed greater bone complexity when compared to patients in the CG. In association with the radiomorphometric analysis of the mental index, we suggest that these locations are possible predictors of incipient changes in the mandibular bone trabeculate in cancer patients using antiresorptive drugs.