Tese (PPGB)https://repositorio.ufba.br/handle/ri/94612026-05-17T06:10:05Z2026-05-17T06:10:05ZEspectrometria de Massas e Molecular Networking como ferramentas para o estudo da diversidade química de espécies nativas de Passiflora L. (Passifloraceae).Garcia, Laryana Borgeshttps://repositorio.ufba.br/handle/ri/439532026-01-30T17:25:54Z0007-07-11T00:00:00ZEspectrometria de Massas e Molecular Networking como ferramentas para o estudo da diversidade química de espécies nativas de Passiflora L. (Passifloraceae).
Garcia, Laryana Borges
Amaral, Juliano Geraldo
The Passifloraceae family, with more than 630 species, is predominant in tropical
and subtropical regions, with Passiflora being the most extensive and diverse genus. This
study aims to deepen the knowledge about the Passifloraceae family and the metabolic
profiles of Passiflora subspecies, known for their rich phytochemical composition,
including glycosylated flavonoids, carotenoids, cyanogenic glycosides, alkaloids,
steroids, lignans, fatty acids, amino acids, chlorogenic acid derivatives and
proanthocyanidins. Initially, we performed a comprehensive review covering studies
from 1983 to 2023, offering a detailed overview of the scientific discoveries on the
chemical compounds present in the genus Passiflora. Then, we combined mass
spectrometry and molecular networking to explore the chemical diversity of native
species of the genus Passiflora from Brazil. We developed a comprehensive database
using liquid chromatography coupled to mass spectrometry (HPLC-MS/MS) to analyze
the metabolic profile of several subspecies. The generated data were submitted to the
GNPS platform, which generated a Molecular Networking, in which the same substances
were grouped in a single node and the similar ones in clusters. The data generated by the
network were dereplicated and also analyzed by multivariate statistical methods, and thus
this work revealed metabolic similarities between species, such as P. incarnata,
suggesting shared pharmacological potential. We documented 25 species not previously
studied, expanding the knowledge about their medicinal properties and opening paths for
the development of new products.
Universidade Federal da Bahia
Dissertação
0007-07-11T00:00:00Z