Inhibition of spermatogenesis in men with monthly injections of medroxyprogesterone acetate and testosterone enanthate

Abstract

Twenty-five healthy men were treated with monthly Jectlons of I00 mg of dro progesterone acetate ) and 250 of testosterone e nthate ( ) for peri s fr 4 to 16 nths. 24/25 sub~ects~ a r d drop spe co t occurred by 1-3 months loll the f st c .... ed ject£ons of A and . Eleven subjects out of 14 o C feted 9 nths of trea nt bec azoospe Ic developed mar d ol~gozoospe ia. Of the 8 n treated for 12-16 ~onths, only one failed to re spo to the trea ent. subjects rep ted decreased ! Ido a potency; 4 jeers reported creased libido a potency, ere re no cha es the size s c .... s lstency or sensit ity of the testi~ cles or breasts, s ific t cha es oc-c urre d set trans a ses or al I e phosphatase d the trea t. With 2 possible exceptlons~ se triglycerides also se ed to be affected by treatnt. re no changes in blood pressure, weight gain was common. o