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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/7787

Title: Solid phase spectrophotometry for the determination of cobalt in pharmaceutical preparations
Other Titles: Microchimica Acta
Authors: Teixeira, Leonardo Sena Gomes
Costa, Antonio Celso Spinola
Assis, Júlio César Rosa
Ferreira, Sergio Luis Costa
Korn, Mauro
Keywords: Cobalt determination;solid-phase spectrophotometry;1-(2-thiazolylazo)-2-naphthol;pharmaceutical preparations
Issue Date: 2001
Abstract: A new sensitive method exploiting solid-phase spectrophotometry is proposed for the determination of cobalt in pharmaceutical preparations. The chromogenic reagent 1-(2-thiazolylazo)-2-naphthol (TAN) was immobilized on C18 bonded silica loaded into a home-made cell with 1.5 mm of optical path for cobalt determination. Cobalt(II) reacts with TAN on C18 material, at pH 6.0–7.5, to give a coloured complex which has maximum absorption at 572 nm. In this way, the sample was passed through the cell and Co(II) ions were quantitatively retained on the solid-phase. After the direct measurement of light-absorption in the solid phase, only the cobalt was eluted with 0.1 mol L−1 hydrochloric acid. The cell was washed with water and then another sample solution could be passed through the cell. The procedure allowed the determination of cobalt in the range of 10–160 μg L−1 with coefficient of variation of 4.7% (n=10) and apparent molar absorptivity of 2.62 × 106 L mol−1 cm−1 using sample volume of 3-mL.
Description: Texto completo: acesso restrito. p. 29-33
URI: http://www.repositorio.ufba.br/ri/handle/ri/7787
ISSN: 0026-3672
Appears in Collections:Artigos Publicados em Periódicos (Quimica)

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