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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/7672

Title: Action of selective serotonin reuptake inhibitor on aggressive behavior in adult rat submitted to the neonatal malnutrition
Other Titles: Arquivos de Neuro-Psiquiatria
Authors: Medeiros, Jairza Maria Barreto
Silva, Cristiano Mendes da
Sougey, Everton Botelho
Costa, José Audisio
Castro, Célia Maria M. Barbosa de
Castro, Raul Manhães de
Keywords: aggressive behavior;malnutrition;serotonin
Issue Date: 2001
Abstract: The effect of the malnutrition during suckling on the aggressiveness was investigated in adult rats treated or not with citalopram, a selective serotonin reuptake inhibitor (SSRI). The animals were divided into two groups according to the diet used: nourished group¾ the rats received the control diet with 23% protein during the life; and malnourished group¾ the rats had its mothers submitted to diet with 7.8% protein during suckling. At 120 days of age, each group was sub-divided according to the treatment: acute ¾ consisting a single i.p. injection of saline solution or 20-mg/Kg citalopram; chronic ¾ consisting the single injections (1 per day during 14 days) of saline or 20 mg/Kg citalopram. The acute or chronic treatment with SSRI reduces aggressive response in nourished rats, but not in malnourished ones. Thus, the malnutrition during the critical period of brain development seems to induce durable alterations in the function of the serotoninergic neurotransmission
Description: p. 499-503
URI: http://www.repositorio.ufba.br/ri/handle/ri/7672
ISSN: 0004-282X
Appears in Collections:Artigos Publicados em Periódicos (Nutrição)

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