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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/7149

Title: Vascular endothelial growth factor (VEGF) levels as a tool to discriminate between malignant and nonmalignant ascites
Other Titles: APMIS
Authors: Nascimento, Ivana Lúcia de Oliveira
Schaer, Robert Eduard
Lemaire, Denise Carneiro
Freire, S.
Paule, B.
Carvalho, Sabrina
Nascimento, Roberto José Meyer
Schaer-Barbosa, Helenemarie
Keywords: VEGF;angiogenesis;ascites;diagnosis
Issue Date: 2004
Abstract: Ascites formation is commonly associated with cancer, although it is also present in other diseases.The aim of this study was to evaluate the usefulness of vascular endothelial growth factor as a malignancy marker in ascites of different etiologies. The levels of VEGF in 32 malignant and in 31 nonmalignant ascites were determined by enzyme immunoassay (ELISA). VEGF levels were significantly higher in malignant than in non-malignant ascites (medianΩ1265.9 pg/ml¿114.6 pg/ml; p 0.0001).We observed 72% sensitivity and 90% specificity, using 662 pg/ml as a cut-off value. Therefore, this approach can be used as a marker for a first screening to discriminate between malignant and nonmalignantascites.
Description: p. 585-587
URI: http://www.repositorio.ufba.br/ri/handle/ri/7149
ISSN: 0903-4641
Appears in Collections:Artigos Publicados em Periódicos (ICS)

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