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|Title: ||Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia|
|Other Titles: ||Brazilian Journal of Medical and Biological Research|
|Authors: ||Castro, L.|
Rocha Junior, M. A.
Fregoneze, J. B.
Castro e Silva, E. de
|Keywords: ||5-HT4 receptors;Water intake;Hyperosmolarity;Hypovolemia|
|Issue Date: ||Jun-2001|
|Publisher: ||Brazilian Journal of Medical and Biological Research|
|Abstract: ||We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 ± 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 ± 0.41 ml, N = 12; salt load + saline = 5.74 ± 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared to hypovolemic animals receiving third ventricle injections of saline (hypovol + GR = 4.01 ± 0.27 ml, N = 8; hypovol + saline = 2.41 ± 0.23 ml, N = 12). We suggest that central 5-HT4 receptors may exert a positive drive on water intake due to hyperosmolarity and a negative input on drinking provoked by hypovolemia.|
|Appears in Collections:||Artigos Publicados em Periódicos (Biologia)|
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