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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6828

Title: Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
Other Titles: Brazilian Journal of Medical and Biological Research
Authors: Castro, L.
Varjão, B.
Silva, I.
Duque, Bruno
Batista, A.
Santana, R.
Luz, P.
Rocha Junior, M. A.
Fregoneze, J. B.
Castro e Silva, E. de
Keywords: 5-HT4 receptors;Water intake;Hyperosmolarity;Hypovolemia
Issue Date: Jun-2001
Publisher: Brazilian Journal of Medical and Biological Research
Abstract: We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 ± 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 ± 0.41 ml, N = 12; salt load + saline = 5.74 ± 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared to hypovolemic animals receiving third ventricle injections of saline (hypovol + GR = 4.01 ± 0.27 ml, N = 8; hypovol + saline = 2.41 ± 0.23 ml, N = 12). We suggest that central 5-HT4 receptors may exert a positive drive on water intake due to hyperosmolarity and a negative input on drinking provoked by hypovolemia.
Description: p.791-796
URI: http://www.repositorio.ufba.br/ri/handle/ri/6828
ISSN: 1414-431X
Appears in Collections:Artigos Publicados em Periódicos (Biologia)

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