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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6524

Title: Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region: Epidemiologic and biomolecular study
Other Titles: Hepatology
Authors: Lobato, Cirley
Tavares-Neto, José
Leite, Márcio Rios
Trepo, Christian
Vitvitski, Ludmila
Parvaz, Parviz
Zoulim, Fabien
D'Oliveira Junior, Argemiro
Paraná, Raymundo
Issue Date: 2006
Publisher: Hepatology
Abstract: Background: Hepatitis B is endemic in the Amazon region. Methods: Serological markers for hepatitis B virus (HBV) were determined in 266 household members for hepatitis B surface antigen (HBsAg)-positive women (G1) and 395 household members for HBsAg-negative women (G2), randomly selected in Acre State Women’s Medical Care Program, in order to evaluate the prevalence of HBV in this population. Before blood sample collection an epidemiological questionnaire was applied. Results: The overall prevalence of HBV carriers (HBsAg) and exposed individuals (anti-HBc, IgG) was, respectively, 21.1% and 60.5% in G1 and 2.8% and 27.4% in G2 ( P < 0.0000001). The frequency of HBsAg was higher among siblings from group G1 (75%) compared to the absence of any HBsAg-positive sibling in G2 ( P < 0.00006). The HBV markers in other family members was as follows: G1 parents, 27.3% vs 4.5% ( P < 0.03), sexual partners, 21.1% vs 2.5% ( P < 0.04), and offspring, 10.4% vs 1.5% ( P < 0.04). A low prevalence of HBsAg and anti-HBc (IgG) was observed for the last offspring of G2 mothers compared to the high prevalence among children of G1 mothers (0% vs 18.2%, P < 0.01 and 2.3% vs 59.1%, P < 0.0000005, respectively), with children younger than 1 year being the most affected. The frequency of the habit of sharing toothbrushes and the presence of at least one HBsAg carrier were higher in G1 than in G2 ( P < 0.0001 and P < 0.000002), respectively. Genotypes A, D and G were found to be predominant by Innolipa test. There were cases that reacted to more than one genotype. Conclusion: Intrafamilial transmission of HBV is evident in the present study and is possibly associated with the presence of more than one HBV carrier in the family and the shared use of toothbrushes among household contacts. Genotype analysis confirms intrafamilial transmission.
Description: RESTRITO
URI: http://www.repositorio.ufba.br/ri/handle/ri/6524
ISSN: 0270-9139
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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