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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6432

Title: Profile of autoantibodies in Jaccoud's arthropathy
Other Titles: Joint Bone Spine
Authors: Galvão, Verena
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Motta, Marina P.
Dourado, Stella Moreira
Grimaldi, Lara
Silva, Natália Oliveira e
Oliveira, Isabela Silva de
Santiago, Mittermayer Barreto
Keywords: Systemic lupus erythematosus;Accoud's arthropathy;Autoantibodies
Issue Date: Jun-2009
Publisher: Elsevier
Abstract: To compare the frequency of different autoantibodies in a group of patients with Jaccoud's arthropathy (JA) secondary to systemic lupus erythematosus (SLE) with those without JA. A group of SLE patients with JA was compared with another group of SLE patients without this complication, matched by age and gender, regarding the presence of autoantibodies. Antibodies to cyclical citrullinated peptides (anti-CCP) and to mutated citrullinated vimentin (anti-MCV) as well as anti-SSA/Ro, anti-SSB/La, anti-Sm and anti-RNP and anticardiolipin (aCL) antibodies were searched by ELISA, using commercial kits. Rheumatoid factor was determined by nephelometry and antinuclear and anti-dsDNA antibodies by IIF. Forty-eight individuals were included in the study, being 24 patients with JA and 24 without JA, matched by gender and age. The frequency of anti-CCP antibodies in the whole population was 12.5% (6 cases), with no difference between the 2 groups. Anti-MCV antibodies were detected in 10.4% (5 cases), being found only in those with JA (p = 0.05). There was no association between the presence of JA and aCL, anti-Sm, anti-RNP and anti-SSB/La antibodies. On the other hand, a statistically significant association between the presence of anti-dsDNA antibodies and JA was observed (p = 0.04) as well as a marginal association with a decrease in serum levels of C3 (p = 0.06). In the present study, there was an association between the presence of JA and anti-dsDNA antibodies, and anti-MCV antibodies were found only in those SLE patients with JA. Whether these antibodies have an etiopathogenic role in JA is entirely unknown.
Description: Trabalho completo: acesso restrito, p.356–360
URI: http://www.repositorio.ufba.br/ri/handle/ri/6432
ISSN: 1297-319X
Appears in Collections:Artigos Publicados em Periódicos (FARMACIA)

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