RI UFBA >
Faculdade de Medicina da Bahia >
Artigos Publicados em Periódicos (Medicina) >
Please use this identifier to cite or link to this item:
|Title: ||Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans|
|Other Titles: ||ACTA Tropica|
|Authors: ||Athanazio, Daniel Abensur|
Santos, Cleiton S.
Santos, Andréia C.
McBride, Flávia W.C.
Reis, Mitermayer Galvão dos
|Keywords: ||Leptospirosis;Leptospira;Mice;Knockout;Cytokines;Animal disease models|
|Issue Date: ||2008|
|Abstract: ||Only recently, knockout mouse models were applied in studies on the pathogenesis of leptospirosis. Current data suggest an important role of innate immunity receptors and interferon dependant cellular response on protection. It is not clear, however, whether T helper cell polarization influences
on outcome of leptospiral infection. We report findings of experimental infection of C57BL/6 (interferon or tumor necrosis factor receptor deficient) and BALB/c (interleukin 4 deficient) mice infected by pathogenic Leptospira interrogans serovar Copenhageni. Specific cytokine gene
deficiency had no impact on outcome since all animals survived. TNFR knockout mice, however, exhibited more severe residual renal inflammation during convalescence thus suggesting this cytokine is important in early control of infection, protecting kidneys from relevant pathology.|
|Description: ||Acesso restrito: Texto completo. p. 95-98.|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.