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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6427

Title: Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
Other Titles: ACTA Tropica
Authors: Athanazio, Daniel Abensur
Santos, Cleiton S.
Santos, Andréia C.
McBride, Flávia W.C.
Reis, Mitermayer Galvão dos
Keywords: Leptospirosis;Leptospira;Mice;Knockout;Cytokines;Animal disease models
Issue Date: 2008
Abstract: Only recently, knockout mouse models were applied in studies on the pathogenesis of leptospirosis. Current data suggest an important role of innate immunity receptors and interferon dependant cellular response on protection. It is not clear, however, whether T helper cell polarization influences on outcome of leptospiral infection. We report findings of experimental infection of C57BL/6 (interferon or tumor necrosis factor receptor deficient) and BALB/c (interleukin 4 deficient) mice infected by pathogenic Leptospira interrogans serovar Copenhageni. Specific cytokine gene deficiency had no impact on outcome since all animals survived. TNFR knockout mice, however, exhibited more severe residual renal inflammation during convalescence thus suggesting this cytokine is important in early control of infection, protecting kidneys from relevant pathology.
Description: Acesso restrito: Texto completo. p. 95-98.
URI: http://www.repositorio.ufba.br/ri/handle/ri/6427
ISSN: 0001-706X
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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