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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6358

Title: Poor zinc and selenium status in phenylketonuric children and adolescents in Brazil
Other Titles: Nutrition Researsh
Authors: Barretto, Junaura Rocha
Silva, Luciana Rodrigues
Leite, Maria Efigênia de Queiroz
Boa Sorte, Ney Cristian Amaral
Pimentel, Helena
Purificação, Antonio Conceição
Carvalho, Gildasio
Fontes, Maria Inês Mattos Miranda
Boa Sorte, Tatiana Regia Suzana Amorim
Keywords: Zinc;Selenium;Copper;Dietary therapy;Humans;Phenylketonuria;DRI;dietary reference intake;PKU;phenylketonuria;RDA;recommended dietary allowance
Issue Date: 2008
Abstract: Because of the restricted intake of high-biologic-value protein, children with phenylketonuria (PKU) may have lower than normal plasma concentrations of copper, zinc, and selenium. The purpose of the present study was to investigate erythrocyte zinc levels and serum copper and selenium levels in children and adolescents with PKU by analyzing the relation between their diet and the laboratory profiles of these elements. The study was conducted in 32 children and adolescents with PKU, who were on a special diet. Dietary records and blood samples were collected from each subject. Erythrocyte zinc and serum selenium levels were below normal in 37.5% and 90.6% of the subjects, respectively. Plasma copper levels were normal. Metabolic formulas were the only source of 86.9% of the zinc, 65.6% of the copper, and 32.4% of the selenium. Despite this, there was no significant correlation between the zinc formula supply and erythrocyte zinc levels (ρ =−0.143, P = .435) or the supply and serum levels for copper (ρ = −0.117, P = .523) and selenium (ρ = 0.113, P = .538). These results suggest that Brazilian patients with PKU present with low ingestion levels, low serum selenium levels, and low erythrocyte zinc levels.
Description: Acesso restrito: Texto completo. p. 208-211.
URI: http://www.repositorio.ufba.br/ri/handle/ri/6358
ISSN: 0271-5317
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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