RI UFBA >
Instituto de Química >
Artigos Publicados em Periódicos (Quimica) >
Please use this identifier to cite or link to this item:
|Title: ||Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis|
|Other Titles: ||Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences|
|Authors: ||Oliveira, Lidia S. de|
Rodrigues, Frederico de M.
Oliveira, Fábio Santos de
Mesquita, Paulo Roberto Ribeiro de
Leal, Danielle C.
Alcântara, Adriano Costa de
Souza, Bárbara Maria Paraná da Silva
Franke, Carlos R.
Pereira, Pedro Afonso de Paula
Andrade, Jailson Bittencourt de
|Keywords: ||Canine hair;VOCs;HS-SPME/GC–MS;Multivariate optimization;PCA;Diagnosis;Visceral leishmaniasis|
|Issue Date: ||2008|
|Abstract: ||A new analytical methodology using HS-SPME/GC–MS was optimized in order to attain maximum sensitivity, using multivariate strategies. The proposed method was employed to evaluate the VOC profile
exhaled fromcanine hair samples collected from 8 healthy dogs and from 16 dogs infected by Leishmania infantum. 274 VOCs were detected, which could be identified as aldehydes, ketones and hydrocarbons.
After application of the Soft Independent Modeling of Class Analogy (SIMCA) and Principal Component Analysis (PCA) healthy and infected dogs, with similar VOCs profiles, could be separately grouped, based
on compounds such as 2-hexanone, benzaldehyde, and 2,4-nonadienal. The proposed method is noninvasive,
painless, readily accepted by dog owners and could be useful to identify several biomarkers with applications in the diagnosis of diseases.|
|Description: ||Acesso restrito: Texto completo. p. 392-398|
|Appears in Collections:||Artigos Publicados em Periódicos (Quimica)|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.