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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5998

Title: Headspace solid phase microextraction/gas chromatography–mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: A new tool to detect dog contamination by visceral leishmaniasis
Other Titles: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Authors: Oliveira, Lidia S. de
Rodrigues, Frederico de M.
Oliveira, Fábio Santos de
Mesquita, Paulo Roberto Ribeiro de
Leal, Danielle C.
Alcântara, Adriano Costa de
Souza, Bárbara Maria Paraná da Silva
Franke, Carlos R.
Pereira, Pedro Afonso de Paula
Andrade, Jailson Bittencourt de
Keywords: Canine hair;VOCs;HS-SPME/GC–MS;Multivariate optimization;PCA;Diagnosis;Visceral leishmaniasis
Issue Date: 2008
Abstract: A new analytical methodology using HS-SPME/GC–MS was optimized in order to attain maximum sensitivity, using multivariate strategies. The proposed method was employed to evaluate the VOC profile exhaled fromcanine hair samples collected from 8 healthy dogs and from 16 dogs infected by Leishmania infantum. 274 VOCs were detected, which could be identified as aldehydes, ketones and hydrocarbons. After application of the Soft Independent Modeling of Class Analogy (SIMCA) and Principal Component Analysis (PCA) healthy and infected dogs, with similar VOCs profiles, could be separately grouped, based on compounds such as 2-hexanone, benzaldehyde, and 2,4-nonadienal. The proposed method is noninvasive, painless, readily accepted by dog owners and could be useful to identify several biomarkers with applications in the diagnosis of diseases.
Description: Acesso restrito: Texto completo. p. 392-398
URI: http://www.repositorio.ufba.br/ri/handle/ri/5998
ISSN: 1570-0232
Appears in Collections:Artigos Publicados em Periódicos (Quimica)

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