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|Title: ||Ocular lesions in sickle cell disease patients from Bahia, Brazil|
|Other Titles: ||Revista Brasileira de Oftalmologia|
|Authors: ||Cury, Dayse|
Boa Sorte, Ney Cristian Amaral
Lyra, Isa Menezes
Zanette, Angela Maria Dias
Gonçalves, Marilda Souza
|Keywords: ||Anemia;sickle cell;Hemoglobin SC disease;Eye injuries;Retinal diseases|
|Issue Date: ||2010|
|Abstract: ||OBJECTIVE: The present study aims to describe ocular alterations in sickle cell disease patients in Bahia, a Northeast state, with the highest prevalence of the disease in Brazil.
METHODS: We carried out a cross-sectional study in a group of 146 (292 eyes) sickle cell disease patients (90 HBSS and 56 HBSC). Ophthalmologic examination including indirect binocular ophthalmoscopy was performed. Examination was completed by fluorescein angiography to detect retinal lesions.
RESULTS: The most frequent ocular lesions identified were "vascular tortuosity" and "black sunburst". Proliferative retinopathy was found in 22 (12.2%) eyes of HBSS patients and 25 (22.3%) eyes of HBSC patients (OR=2.06; CI95%: 1.5-4.06, p=0.022); Its frequency was higher among HBSS patients aged 20-39 years, while in HBSC patients, it peaked after 40 years (35.7% and 42.8%) and dropped sharply afterwards.
CONCLUSION: Proliferative retinopathy was described as early as 10 years of age in both patients groups. Proliferative sickle retinopathy can result in blindness and the knowledge of the most prevalent ocular alterations and age risk will be important to establish a protocol of ophthalmologic follow-up, in order to prevent a severe visual loss and increase patient's life quality.|
|Description: ||p. 259-263.|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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