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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5500

Title: Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats
Other Titles: Regulatory Peptides
Authors: Andrade, Everaldo Nery de
Gonçalves, Gleisy Kelly Neves
Oliveira, Thiago Henrique Caldeira de
Santos, Caroline Silva dos
Souza, Clarissa Leal Silva e
Firmes, Luciana Barbosa
Magalhães, Amélia Cristina Mendes de
Soares, Telma de Jesus
Reis, Adelina Martha dos
Belo, Najara de Oliveira
Keywords: Estrogen;Obesity;ANP;High blood pressure
Issue Date: 2011
Abstract: The present study was designed to develop an animal model of hypertension and cardiac hypertrophy associated with obesity in female rats. Furthermore, we studied the involvement of the natriuretic peptide system in the mechanisms of these conditions. Obesity was induced in Wistar rats by a high fat diet and ovariectomy. The rats were divided into four groups: ovariectomized or sham-operated with high-fat diet and ovariectomized or sham-operated with control diet. After 24 weeks of diet, rats were killed, and their tissues were removed. Cardiac atrial natriuretic peptide (ANP), clearance receptor (NPr-C) gene expression was determined by PCR. ANP concentrations were measured in plasma. Ovariectomized fat-fed rats (OF) showed increased body weight, visceral fat depot and blood pressure and decreased sodium excretion compared to other groups. Also, these rats showed higher heart-to-body weight and cell diameters of ventricular cardiomyocytes and lower cardiac ANP mRNA and plasma ANP than the control group. The adipocyte and renal NPr-C mRNA of OF rats were higher than the control group. These data showed that combined ovariectomy and high fat diet elicited obesity, hypertension and cardiac hypertrophy. These results suggest that the impairment of the natriuretic peptide system may be one of the mechanisms involved not only in development of hypertension but also in cardiac hypertrophy associated with obesity in ovariectomized rats.
Description: texto completo: acesso restrito. p. 149–155.
URI: http://www.repositorio.ufba.br/ri/handle/ri/5500
ISSN: 1873-1686
Appears in Collections:Artigos Publicados em Periódicos (IMS)

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