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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5218

Title: HTLV-1 and myelopathy in Salvador (Northeastern Brazil)
Other Titles: Arquivos de Neuro-Psiquiatria
Authors: Lessa, Inês
Moraes, Dilcineia
Moura, Luciana
Melo, Ailton de Souza
Keywords: HTLV-1;retrovirus;analytical studies;tropical spastic paraparesis;Brazil
Issue Date: 1993
Abstract: The principal aim of the study was to determine the degree of association between cerebrospinal fluid (CSF) that is positive for HTLV-1 and myelopathy in Salvador, Brazil. From the same hospital, twenty-eight cases of myelopathy and twenty-eight cases showing no neurological disorder were studied using blind selection matched 1:1 by age and sex. The twenty-eight pairs underwent HTLV-1 serology tests. In thos« with a positive result, anti-HTLV-1 antibodies were investigated in the CSF. The ELISA method was used, complemented by the Western-blot test. Myelopathy was considered associated with HTLV-1 only when the CSF was positive indicating neurotropism of the virus. The mean age of the cases was 44.6 ± 15.6 years and the control group was 43.5 ± 16.0 (p]>0.05). An OR of 9.0 was detected with a reability interval (95%) of 1.652-48.866 and chi-square significant at the 0.02 level. Despite a strong degree of association and considering the low level of precision, there is a need for analytical studies with larger samples which besides improving the precision will allow for greater control of the confounding variables.
Description: p. 447-451
URI: http://www.repositorio.ufba.br/ri/handle/ri/5218
ISSN: 1678-4227
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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