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Title: HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
Other Titles: The Brazilian Journal of Infectious
Authors: Silva, Edinete Melo da
Acosta, Angelina Xavier
Santos, Eduardo José Melo
Martins Netto, Eduardo
Lemaire, Denise Carneiro
Oliveira, Adriano Silva
Barbosa, Carolina Matos
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Castro, Bernardo Galvão
Brites, Carlos
Keywords: HIV;AIDS;MHC;HLA;polymorphism
Issue Date: 2010
Abstract: Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. Objective: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. Methods: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specifi c oligonucleotide probes following amplifi cation of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher´s exact and ANOVA tests for categorical and continuous variables, respectively. Results: We detected a signifi cant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia  1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia  1,800 copies/mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a signifi cantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p ≤ 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. Conclusion: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These fi ndings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population.
Description: p.468-475
URI: http://www.repositorio.ufba.br/ri/handle/ri/5048
ISSN: 1678-4391
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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