DSpace

RI UFBA >
Instituto de Saúde Coletiva - ISC >
Artigos Publicados em Periódicos Estrangeiros (ISC) >

Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/2838

Title: Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study
Other Titles: BMC Pulm Med
Authors: Veiga, Rafael Valente
Cunha, Sergio S.
Dattoli, Vitor Camilo Cavalcante
Cruz Filho, Álvaro Augusto Souza da
Cooper, Phillip J.
Rodrigues, Laura C.
Barreto, Mauricio Lima
Alcântara-Neves, Neuza Maria
Keywords: Asthma;Virus Diseases;Children
Issue Date: 2011
Abstract: Background: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increased exposure to infections may provide protection against the development of allergy. In this work we investigated the association between exposure to viral infections in children living in urban Brazil and the prevalence of atopy and asthma. Methods: School age children living in poor neighborhoods in the city of Salvador were studied. Data on asthma symptoms and relevant risk factors were obtained by questionnaire. Skin prick tests (SPTs) were performed to seven aeroallergens, and specific IgE was measured to four of these. Viral infections were determined by the presence of specific IgG in serum to Herpes simplex (HSV), Herpes zoster (HZV), Epstein-Barr (EBV), and Hepatitis A (HAV) viruses. Results: A total of 644 (49.7%) children had at least one allergen-specific IgE> 0.35 kU/L and 489 (37.7%) had specific IgE> 0.70 kU/L. A total of 391 (30.2%) children were skin test positive (SPT+), and 295 (22.8%) children were asthmatic. The seroprevalence of viral infections was 88.9% for EBV, 55.4% for HSV, 45.5% for VZV and 17.5% for HAV. Negative associations were observed between SPT+ and HSV (OR = 0.64, CI = 0.51, 0.82) and EBV (OR = 0.63,CI = 0.44, 0.89) infections, but no associations were seen between viral infections and the presence of allergenspecific IgE or asthma. Conclusion: These data do not support previous data showing a protective effect of HAV against atopy, but did show inverse associations between SPT+ (but not specific IgE+) and infections with HSV and EBV. These findings suggest that different viral infections may protect against SPT+ in different settings and may indicate an immunoregulatory role of such infections on immediate ypersensitivity responses. The data provide no support for a protective effect of viral infections against asthma in this population.
URI: http://www.repositorio.ufba.br/ri/handle/ri/2838
ISSN: 1471-2466
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

Files in This Item:

File Description SizeFormat
Per Inter 2011.3.pdf237.87 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

    Universidade Federal da Bahia

Contate-nos. Saiba mais sobre o RI/UFBA